Chang Y, et al. (1998) Am J Resp Clin Care Med 157(2): 594-598. Chin LS, etal. (2001) J Agr Food Chem 49(6): 3101-3105.

Warning: Since 1994, an endemic of chronic obstructive pulmonary disease has developed in Taiwan after intake of Sauropus androgynus (L.) Merr. to reduce body weight. Biopsy of lung specimens from the patients revealed bronchiolitis obliterans. A few patients died, but many developed protracted chronic respiratory failure. As the chronic debilitation and ineffective conventional treatments, single lung transplants were performed as the last resort in four patients. The excised lungs revealed focal fibromuscular sclerosis and obliteration of bronchial arteries in the wall of large bronchi (ChangY etal., 1998).

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