Pharmaceutical potential

Antiplasmodial properties: An extract of Harrisonia abyssinica inhibits the proliferation of chloroquine-resistant strain of Plasmodium falciparum Dd2 at an IC50 value of 4.7 ^g/mL; and the chloroquine-sensitive strain of Plasmodium falciparum 3D7 at an IC50 value of 10^g/mL; (El-Tahir A et a/., 1999). This extract inhibits the proliferation of a broad spectrum of bacter limonoids involved here?

Fig. 234. Harrisonia perforata (Blanco) Merr. From: KLU Herbarium 34828. Flora of Sulawesi (Celebes), Indonesian - Dutch Expedition 1979, sponsored by WOTRO. Ex. Herb. Leiden. Botanical identification: H.P.N. Field collector: van Balgooy, date: 22 Apr 1979. Geographical localization: Central Sulawesi: 0° 30'-1° 30' South-119° 30'-120° 30' East., hills above Donggala, altitude: 100 m, secondary forest on dry calcareous soil.

Fig. 234. Harrisonia perforata (Blanco) Merr. From: KLU Herbarium 34828. Flora of Sulawesi (Celebes), Indonesian - Dutch Expedition 1979, sponsored by WOTRO. Ex. Herb. Leiden. Botanical identification: H.P.N. Field collector: van Balgooy, date: 22 Apr 1979. Geographical localization: Central Sulawesi: 0° 30'-1° 30' South-119° 30'-120° 30' East., hills above Donggala, altitude: 100 m, secondary forest on dry calcareous soil.

Uses: Harrisonia perforata (Blanco) Merr. is used to treat amebic dysentery. In Vietnam, it is used to treat itchiness. In Indonesia and the Philippines, the plant is used to treat dysentry, diarrhea and cholera. In China, the root of this plant is used to prevent and treat malaria and boils.

as well (Fabry W et al., 1998). Are types of chromones, such as perforatic acid (Takana T et al, 1995; Wang MX etal., 1983; 1984).

Perforatic acid (R = COOH)
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