Pharmaceutical interest

Cytotoxic properties: The therapeutic potential of Micromelum hirsutum Oliv. would be worth being assessed as Micromelum species are known to produce cytotoxic coumarins. An extract of Micromelum integerrimum (Buch.-Ham. ex Coleb.) M. Roem. inhibits the proliferation of P388 lymphocytic leukemia cells in mice. Further fractionation of this extracts resulted in the characterization of coumarins: micromelin and scopoletin (Cassady JM et a/., 1979). Micromarin-A, B, C, F, G, and H have been characterized from the stems of Micromelum minutum Wight. et Arn (Ito C et a/., 2000); these are very probably cytotoxic.

Scopoletin

Scopoletin

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