Pharmaceutical interest

Analgesic properties : An ethanolic extract of the bulbs of Narcissus tazetta L. inhibits dose-dependently, in mice, the abdominal contractions induced by p-benzoquinone at doses of 5 mg/Kg, 50 mg/Kg, 100 mg/Kg or 200 mg/Kg, sub-cutaneously, but has no analgesic effect in the hot-plate test (Cakici I et al., 1997).

Antiviral properties: An ethanolic extract of bulbs of Narcissus tazetta L. inhibits the plaque formation of Bovine Rhinotracheitis Virus and Equine Rhinopneu-monitis Virus cultured in vitro (Kelling CL et al., 1976). An alkaloidal extract of Narcissus tazetta L. inhibits DNA polymerase of Avian myeloblastosis Virus (Papas TS etal., 1973).

Cytotoxic property : Two cytotoxic alkaloids N-methyl-8,9-methylenedioxy-phenanthridinium methylsulfate and N-methyl-8,9-methylenedioxy-phenan-thridinium malate are known to occur in the fresh flowers of Narcissus tazetta L. (Youssef DT etal., 2001). Note that lycorine, pseudolycorine, galanthamine, haemanthamine, tazettine and pretazzetine are present as well (Abdallah OM etal., 1993).

Other properties: A number of hemagglutinating mannose-binding dimeric lectins were isolated from the bulb of Narcissus tazetta L. (Ooi LS et al., 2000).

OCHa

Tazettine

OCHa

Tazettine

References

Cakici I, etal. (1997) J Pharm Pharmacol 49(8): 828-830. Kelling CL, etal. (1976) Am J Vet Res 37(2): 215-218. Papas TS, etal. (1973) Biochem Biophys Res Comm 52(1): 88-92. Ooi LS, etal. (2000) Biochem Cell Biol 78(4): 463-468. Youssef DT, etal. (2001) Pharmazie 56(10): 818-822.

Warning: The plant is very toxic.

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