Pharmaceutical interest

Anti-inflammatory properties: Tectorigenin and tectoridin, 2 steroids characterized from the rhizome of Belamcanda chinensis (L.) DC. suppress the production of prostaglandin E2 by rat peritoneal macrophages, stimulated by the protein kinase C activator, 12-0-tetradecanoylphorbol-13-acetate or the endomembrane Ca2+-ATPase inhibitor: thapsigargin. Tectorigenin inhibits the production of prostaglandin E2 more efficiently than tectoridin. Neither compound inhibits the release of radioproperty from [3H]arachidonic acid-labeled macrophages stimulated by 12-0-tetradecanoylphorbol-13-acetate or thapsigargin (Kim YP et al., 1999). Note that tectorigenin inhibits the growth of a number of fungi classified within the genus Trichophyton, at least, the inhibiting concentration ranging from 3.12 mg/mLto6.25 mg/ML (Oh KB et al., 2001).

Hormonalproperty:The causative components for the gynecological use mentioned above are hypothesized to be steroids, since tectorigenin displays some levels of activity on estrogen receptors (Seidlova-Wuttke D et al, 2004).

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