Pharmaceutical interest

Diuretic properties: Ethanol extracts of leaves and seeds inhibit the growth of bacterial burn pathogens cultured in vitro (Gnanamani A et al., 2003), protect rodents against alloxan poisoning (Vetrichelvan T et al, 2002) and promote urination in rodents as efficiently as hydrochlorothiazide (5mg/Kg) standard. The seeds of Celosia argentea L. given per os (4 g) to 10 healthy human volunteers (male, 33-35 years old), increase significantly the secretion of urine (57%; Shah MB etal., 1993).

Celosian: Of particular interest is the fact that an aqueous extract of seeds of Celosia argentea L. given intraperitonneally to animals infected with colon 26-L5 carcinoma cells, reduces significantly liver metastasis through the induction of cytokins (Hayakawa Y et al., 1998). From this extract was characterized the celosian, which is an immunos-timulating and hepatoprotector acidic polysaccharide. Celosian inhibits the elevation of GPT, GOT and bilirubin in carbon tetrachloride-induced liver injury in rats and suppresses mortality on fulminant hepatitis caused

by ß-D-galactosamine/lipopolysaccharide or caused by Propionibacterium acnes/(LP5) in mice. Dose-dependent protection against chemical and immunological hepatitis is observed (Hase K et a/., 1996). Celosian stimulates the production of tumor necrosis factor a (TNFa), 1ß and nitric oxide in macrophage cell-line (1774-1) in a concentration-dependent manner, and promotes the secretion of interleukin 1 ß in human mononuclear cells. Celosian enhances the production of interferon y by concavalin A in mouse spleen cells (Hase K et al., 1997).

Other pharmacological properties: The plant is also interesting because it produces a series of cyclic pep-tides, including celogentin A-C, and K which inhibit the polymerization of tubulin (Kobayashi J et al., 2001; Suzuki et al., 2004). The aerial part of Celosia argentea L. abound with flavonoids which may participate in the anti-inflammatory properties mentioned above. An extract of Celosia argentea L. examined on anti-DNPantibody response in mice suppresses the secretion of IgE antibody in certain allergic disorders (Imago K et al., 1994). An aqueous extract of Celosia argentea L. displays an utero-tonic property on isolated portions of rabbit and guinea-pig uterine horns (Shipochliev T, 1981).

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