Pharmaceutical interest

Diuretic properties: Ethanol extracts of leaves and seeds inhibit the growth of bacterial burn pathogens cultured in vitro (Gnanamani A et al., 2003), protect rodents against alloxan poisoning (Vetrichelvan T et al, 2002) and promote urination in rodents as efficiently as hydrochlorothiazide (5mg/Kg) standard. The seeds of Celosia argentea L. given per os (4 g) to 10 healthy human volunteers (male, 33-35 years old), increase significantly the secretion of urine (57%; Shah MB etal., 1993).

Celosian: Of particular interest is the fact that an aqueous extract of seeds of Celosia argentea L. given intraperitonneally to animals infected with colon 26-L5 carcinoma cells, reduces significantly liver metastasis through the induction of cytokins (Hayakawa Y et al., 1998). From this extract was characterized the celosian, which is an immunos-timulating and hepatoprotector acidic polysaccharide. Celosian inhibits the elevation of GPT, GOT and bilirubin in carbon tetrachloride-induced liver injury in rats and suppresses mortality on fulminant hepatitis caused

by ß-D-galactosamine/lipopolysaccharide or caused by Propionibacterium acnes/(LP5) in mice. Dose-dependent protection against chemical and immunological hepatitis is observed (Hase K et a/., 1996). Celosian stimulates the production of tumor necrosis factor a (TNFa), 1ß and nitric oxide in macrophage cell-line (1774-1) in a concentration-dependent manner, and promotes the secretion of interleukin 1 ß in human mononuclear cells. Celosian enhances the production of interferon y by concavalin A in mouse spleen cells (Hase K et al., 1997).

Other pharmacological properties: The plant is also interesting because it produces a series of cyclic pep-tides, including celogentin A-C, and K which inhibit the polymerization of tubulin (Kobayashi J et al., 2001; Suzuki et al., 2004). The aerial part of Celosia argentea L. abound with flavonoids which may participate in the anti-inflammatory properties mentioned above. An extract of Celosia argentea L. examined on anti-DNPantibody response in mice suppresses the secretion of IgE antibody in certain allergic disorders (Imago K et al., 1994). An aqueous extract of Celosia argentea L. displays an utero-tonic property on isolated portions of rabbit and guinea-pig uterine horns (Shipochliev T, 1981).

Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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