Pharmaceutical interest

Estrogenic properties: Murraya paniculata (L.) Jack produces yuehchukene, a bisindole alkaloid (Kong YC etal., 1985), which inhibits 100% of gestation when given per os or subcutaneously to female mice at a dosage of 2 mg/Kg/day or 4 mg/Kg/day on day 1-3 of gestation. At a dosage of 2 mg/Kg/day or 4 mg/Kg/day for 3 days, it increases the uterine weight in immature mice (Wang NG etal., 1990). Yuehchukene is both estrogenic and antiestrogenic, although structurally rather different from oestradiol. It binds to rat, mice and MCF-7 cell estrogen receptors with a relative binding affinity of 1/150 to 1/300, hence the estrogenic activities. It has been suggested that the free indole moiety of catabolized yuehchukene induces estradiol-2-hydroxylase which is responsible for the catabolism of estrogen (Ng PC et al., 1994). It will be interesting to learn whether a more intensive study of bis-indoles from the genus Murraya will reveal any molecules of therapeutic interest for the treatment of estrogen dependent-cancers.

Other pharmacological properties: Murranganone and paniculatin characterized from the leaves inhibit the enzymatic activity of cholinesterase inhibitors, hence the gastralgic mentioned above (Chowdhury MI eta/., 2002). 9-Formyl-3-methylcarbazole, characterized from Murraya koenigii (curry), inhibits moderately the proliferation of both mouse melanoma B16 and adriamycin-resistant mouse leukemia cell-lines cultured in vitro (Chakrabarty M et a/., 1997). The leaves of Murraya koenigii given to high fat diet-induced rat, reduced the peroxidation level to a beneficial extent (Khan BA et a/., 1997).

Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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