Pharmaceutical interest

Estrogenic properties: Murraya paniculata (L.) Jack produces yuehchukene, a bisindole alkaloid (Kong YC etal., 1985), which inhibits 100% of gestation when given per os or subcutaneously to female mice at a dosage of 2 mg/Kg/day or 4 mg/Kg/day on day 1-3 of gestation. At a dosage of 2 mg/Kg/day or 4 mg/Kg/day for 3 days, it increases the uterine weight in immature mice (Wang NG etal., 1990). Yuehchukene is both estrogenic and antiestrogenic, although structurally rather different from oestradiol. It binds to rat, mice and MCF-7 cell estrogen receptors with a relative binding affinity of 1/150 to 1/300, hence the estrogenic activities. It has been suggested that the free indole moiety of catabolized yuehchukene induces estradiol-2-hydroxylase which is responsible for the catabolism of estrogen (Ng PC et al., 1994). It will be interesting to learn whether a more intensive study of bis-indoles from the genus Murraya will reveal any molecules of therapeutic interest for the treatment of estrogen dependent-cancers.

Other pharmacological properties: Murranganone and paniculatin characterized from the leaves inhibit the enzymatic activity of cholinesterase inhibitors, hence the gastralgic mentioned above (Chowdhury MI eta/., 2002). 9-Formyl-3-methylcarbazole, characterized from Murraya koenigii (curry), inhibits moderately the proliferation of both mouse melanoma B16 and adriamycin-resistant mouse leukemia cell-lines cultured in vitro (Chakrabarty M et a/., 1997). The leaves of Murraya koenigii given to high fat diet-induced rat, reduced the peroxidation level to a beneficial extent (Khan BA et a/., 1997).

Diabetes 2

Diabetes 2

Diabetes is a disease that affects the way your body uses food. Normally, your body converts sugars, starches and other foods into a form of sugar called glucose. Your body uses glucose for fuel. The cells receive the glucose through the bloodstream. They then use insulin a hormone made by the pancreas to absorb the glucose, convert it into energy, and either use it or store it for later use. Learn more...

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