Pharmaceutical interest

Antimicrobial properties: The essential oil of Ageratum conyzoides L. inhibits the proliferation of several Gram-positive and Gram-negative bacteria and fungi cultured in vitro (Pattnaik S etal., 1996).

Cardiovascular properties: An aqueous extract of Ageratum conyzoides L. given peros (0.1 g/Kg to 5 g/Kg) calms and lowers the spontaneous motility of rodent. The sleeping time caused by sodium pentobarbital (50mg/Kg, intraperitonneal injection) in mice is not altered by previous treatment with the aqueous extract (2 g/Kg, per os). In isolated guinea pig ilea, the aqueous extract (0.01 mg/mL-10mg/mL) contracts dose-dependently ileal smooth muscle portions and this effect is blocked by diphenhydramine (10 nM) and reduced by 32% in the presence of atropine (10 nM). In vitro the extract displays histamine-like property (Yamamoto LA et al., 1991). An extract of the leaves of Ageratum cony-zoides L. changed the electrocardiogram, the atrial impulse velocity and the coronary vessels, resistance of isolated guinea pig hearts (Garcia EA et al., 1999). Is the principle involved one of pyrrolizidine alkaloid?

Other properties: Anti-inflammatory and chronic toxicity study of the leaves of Ageratum conyzoides L. in rats are reported by Moura et al. (2005).

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