Pharmaceutical interest

Rottlerin: The dyeing principles of kamala powder are phloroglucinol derivatives: rottlerin (mallotoxin) and isorottlerin. Aqueous and ethanolic extracts of leaves of Mallotus philippensis (Lamk.) Muell. Arg. inhibit the spontaneous mobility of Setaria cervie microfilariae with an LC50 value of 18ng/mL and LC90: 20ng/mL (Singh R et al., 1997). This property is most probably due to the presence of rottlerin, which is known to destroy intestinal worms efficiently, possibly through inhibition of calmodulin-dependent protein kinase III (Parmer TG et al., 1997) that phosphorylates a number of substrates that regulate the proliferation of cells upon mitogen stimulation.

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