Pharmaceutical interest

Trans-dehydrocrotonin.Trans-dehydro-crotonin, a clerodane diterpene characterized from Croton cajucara Benth. inhibits the development of ulcers caused by ethanol and stress in animals, and lowers glycemia in rats treated with alloxan (Farias RA et al., 1997). Trans-dehydrocrotonin has a moderate acute toxicity LD50: 878 mg/Kg, peros, in mice and inhibits the growth of HL60 cells cultured in vitro by inducing apoptosis (Anazetti MC et al, 2003). It will be interesting to learn whether a more intensive study on Croton argyratus Bl. will reveal diterpenes of pharmacological interest.

Fig. 202. Croton argyratus Bl.

Uses: In Malaysia, a decoction of the leaves of Croton argyratus Bl. is used to aid recovery from childbirth, and to stop diarrhea. The leaves are used to combat fever. In Vietnam, the leaves are boiled in water and the decoction obtained is drunk to invigorate the body.

Other properties: The aerial parts of Croton ruizianus contain a number of pregnane glycosides with proag-gregating property (Piaciente S et al., 1998). Aleuri-tolic acid characterized from Croton urucurana Baillon inhibits the proliferation of Staphyloccocus aureus and Salmonella thyphimurium (Peres MT et al., 1997).

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