Pharmaceutical interest

Chemotherapeutic properties: Aceto-genins: Uvarigrin, an acetogenin characterized from the roots of Uvaria grandiflora Roxb, inhibits the growth of HCT-8, BeI7402 and A2780 human tumor cells with ED50 of 0.15 ^g/mL, 0.21 ^g/mL and 0.41 ^g/mL respectively (Pan XP et al., 1997). A number of triterpenes (glutinol, glutinone, taraxerol, ß-sitosterol) and aceto-genins (uvariamicin I-III, squamocin, squamocin-28-one, narumicin I-II, characterized from Uvaria narum and Uvaria hookeri inhibit the proliferation of several sorts of microorganisms including cocci: Staphylococcus pyogene; bacilli: Bacillus brevis, Bacillus circulans, Bacillus licheniformis, Salmonella thyphi, Escherichia coli, Klebsiella aerogene, Pseudomonas pyocyaneae; and fungi: Aspergillus niger, Penicillium notatum, Trichophyton mentagrophytes, Microsporum gipsum, Epidermophyton floccosum. A number of these acetogenins destroy Haemonchus contortus as efficiently as a mebendazole (Vermox®; PadmajaV etal., 1993). Root bark extracts of Uvaria narum and Uvaria hookeri are cytotoxic on probable account of acetogenins (PadjamaV etal., 1995).

The essential oil extracted from the root bark of Uvaria narum is calming, stops flatulence and counteracts putrefaction. This oil contains 15% of bornyl acetate, 8% of patchoulinone and a tricyclic sesquiterpene ketone.

Flavonoids: An interesting feature of the Uvaria species is the occurrence of C-benzylated flavonoids such as uvaretin and isouvaretin characterized from Uvaria chamae(Hufford CD etal., 1976; 1978), or triuvaretin and isotriuvaretin, Taraxerol

Fig. 15. Uvaria grandiflora Roxb. From: KLU 037294. Field Collector: SC Chin & Mustafa, 4 Feb 1985. Geographical localization: Sungai Layang, in old rubber estate, Negeri Sembilan, Malaysia.

isodesacetyluvaricin and panalicin)

characterized from the root bark of Uvaria leptocladon (Nkunya MHH et al., 1993). Extracts of the bark of Uvaria lucida and the root bark of Uvaria scheffleri destroy efficiently the multidrug-resistant K1 strain of Plasmodium falciparum on account of uvaretin (IC50 = 3.49 ^g/mL) and diuvaretin (IC50 = 4.2 ^g/mL; Nkunya MH et al., 1991). Hamiltrone, an aurone characterized from Uvaria hamiltonii, has a strong DNA strand-scission property (Huang L et al., 1998). Chamuvaretin, a dihydrobenzylchalcone from Uvaria chamae, induces mutations in TA98 and TA 100 strains Salmonella thyphimurium (Uwaifo AO et al., 1979).

Uvaretin

Uvaretin

H3CO'

H3CO'

H3CO'

H3CO'

Boldine

Boldine

Isoquinoline alkaloids: An ethanolic extract of the root bark of Uvaria chamae relaxes the smooth muscles of guinea-pig ileum, rabbit jejunum and rat uterus in vitro and in vivo (Langason RBF et al., 1994), and displays anti-ulcerogen, hepatoprotective and trypanocidal properties (Madubunyi II et al., 1996). The antispasmodic property could be attributed to toisoquinolines alkaloid which are known to block the muscarinic receptors (see Fissistigma), whereas the hepatoprotective property could involve choleretic aporphinoid boldine-like alkaloids. Boldine is commercially used to treat hepatic disturbances and is currently extracted from Peumus boldus (family Monimiaceae). Boldine is found in a number of plants classified within the genus Desmos which botanically is close to the genus Uvaria.

Baby Sleeping

Baby Sleeping

Everything You Need To Know About Baby Sleeping. Your baby is going to be sleeping a lot. During the first few months, your baby will sleep for most of theday. You may not get any real interaction, or reactions other than sleep and crying.

Get My Free Ebook


Post a comment