Pharmaceutical interest

Chemotherapeutic properties: A meth-anolic extract of Bidens pilosa L. displays a potent antimicrobial property in vitro against Gram-positive bacteria (Rabe T et al., 1997). A chal-cone ester glycoside characterized from Bidens leucantha inhibits moderately the replication of the Human Immunodeficiency Virus (De Tommasi N et al., 1997). Chloroformic and butanolic fractions (50 ^g/mL) of Bidens pilosa L. inhibit up to 90% of the proliferation of Plasmodium falciparum cultured in vitro and lowered parasitaemia in mice (Brandas MG etal., 1997). A water extract of Bidens pilosa var. minor inhibits the growth of a number of leukaemia cell-lines cultured in vitro at dosages ranging from 145 ^g/mL to 586 ^g/mL (Chang JS et al., 2001). An extract of the plant is chemopreventive (Chiang YM et al., 2004).

Gastro-intestinal properties: An aqueous extract of Bidens pilosa L. alleviates dose-dependently the contraction caused by potassium chloride (60 ^M) and noradrenaline (10-5M) on aortic strips with intact and physically damaged endothelium (DimoT etal., 1998). Extracts of Bidens pilosa L. inhibit the enzymatic activity of cyclo-oxygenase in vitro (Jager K et al., 1996) and counteract liver carbon tetrachloride- and acetaminophen-poisoning mice (Chin HW et al., 1996). An ethanolic extract (0.5 g/Kg-2 g/Kg) decreases the gastric juice volume, acid secretion and pepsin secretion in pylorus ligated rats. This extract protects the stomach against indomethacine-induced and ethanol-induced hemorrhagic lesions. This extract inhibits gastric hemorrhagic lesions caused by ethanol, with an effective dose of 2 g/Kg being more potent than sucralfate (400mg/Kg). In contrast, ranitidine (50mg/Kg) failed to lower these lesions (Alvarez A et al., 1999). These gastric effects could be related to cyclo-oxygenase.

Antidiabetes properties: In vivo bioassay-guided fractionation of an alcohol extract of the aerial parts of Bidens pilosa Sch. Bip. var. radiata, using C57 BL/Ks-db/db mice as a model for type 2 diabetes, resulted in the characterization of 2 polyacetylenic glucosides: 2-ß-D-glucopyranosyloxy-1-hydroxy-5(E)-tridecene-7,9,11-triyne and 3-ß-D-glucopyranosyloxy-1-hydro-xy-6(E)-tetradecene-8,10,1 2-triyne (Ubillas RP et al., 2000). It would be

Uses: In China, a decoction of the leaves mixed with rice wine is used to invigorate health after choking, assuage lung discomfort and to check bleeding. In Vietnam, a poultice is used to counteract putrefaction of the eyes. In Malaysia, the leaves are chewed or applied to the gums to assuage toothache. A decoction of the plant is bechic. In Solomon Islands, the roots are used to assuage stomachache.

interesting to understand the exact molecular mechanism in which these glycosides lower the serum levels of glycemia.

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