Pharmaceutical interest

Glycinergic properties: Corymine extracted from the leaves of Hunteria zey-lanica (Retz.) Gardn. &Thw. is interesting because it potentiates the convulsions induced either by strychnine or picrotoxin, at doses of 2, 8 and 15mg/Kg in mice (Leewanich P etal., 1996) and inhibits glycine-gated chlorine-channels by interacting with a site different from that of 4,4 -diisothiocyanostilbene-2,2 -disulfonic acid (Leewanich P et al., 1998).

Uses: In Malaysia, the latex of Hunteria zeylanica (Retz.) Gardn. & Thw. is used to treat yaws.

Anti-inflammatory and antipyretic properties: Alkaloids are very likely to be involved in the medicinal use mentioned above, as a crude alkaloid fraction extracted from the bark at doses of 300 ^g/mL inhibits the production of leukotriene C4 by 5-lipoxygenase by 50% in A23187-stimulated rat mast cells (Reanmongkol W etal., 1995). Strictosidinic acid given to rodent displays antinociceptive effect in the writhing test and lowers the fever induced by yeasts (Reanmongkol W et al., 2000).

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