Pharmaceutical interest

Polysulphides: The garlic smell and the anthelminthic properties of the seeds of Scorodocarpus borneen-sis Becc. are attributed to a very unusual series of polysulphides such as 2,4,5,7-tetrathiaoctane 4,4-dioxide (CH3SCH2SO2SCH2SCH3), 5-thioxo-2,4,6-trithiaheptane 2,2-dioxide (CH3 SO2CH2SCSSCH3), and O-ethyl S-methylthiomethyl thiosulphite (CH3SCH2 SS(O)OCH2CH3 which are drastically antimicrobial and cytotoxic (Lim H et a/., 1998). 2,4,5-trithiahexane, 2,4,5,7-tetrathiaoctane, and 2,4,5,7-tetra-thiaoctane 2,2-dioxide, and 2,4,5,7-tetrathiaoctane 4,4-dioxide inhibit rabbit platelet aggregation induced by collagen, arachidonic acid, U46619, adenosine 5 -diphosphate, platelet aggregating factor, and thrombin. This effect is on account of the inhibition of the arachidonic acid metabolism and aggregation in association with the function of the platelet plasma membrane (Lim H eta/., 1999). Other substances characterized from the seeds are sesquiterpenes scodopin and cadalene-^-carboxylic acid, and a mixture of 3 tryptamine-type alkaloids, scorodocarpines A-C (Wiart C et a/., 2001).

II 3

2,4,5,7 - Tetrathiaoctane 4,4 - dioxide

O - Ethyl S - Methylthiomethyl thiosulphite

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