Pharmaceutical interest

Diterpenes: The latex of Excoecaria agallocha L. owes its irritating property to several sorts of complex diterpenes of the tigliane and daphnane types. One such compound is 12-deoxyphorbol, 13-(3E, 5E-decadienoate) which was characterized as the anti-HIV principle of the leaves and stem of this plant (Erickson KL et a/., 1995). Excoecaria agallocha L. is also known to produce several diterpenes of the labdane, beyerane and kau-rane types, which display anti-tumor activity and inhibit in vitro the activation of the Epstein-Barr virus (EBV) by 12-0-tetradecanoylphorbol-13-acetate (TPA). One such compound is ent-3^-hydroxy-15-beyeren-2-one which displays anti-tumor promoting activity in mice against 7,12-dimethylbenza [a]anthracene (Korishi T et a/., 1998). The roots contain a series of labdane diterpenes such as agallochin A, the pharmacological potential of which remains to be assessed (Anjaneyulu ASR et a/., 2000).

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