Pharmaceutical interest

Fig. 95. Hypericum japonicum Thunb. From: KLU Herbarium 24155. Herbarium Jutlandicum (AAU), Botanisk Institut Aarhus Universitet. Flora of Thailand project, 4th Expedition 1972. Field collectors: Kai Larsen, Supee S Larsen, I Nielsen & T Santisuk. Eastern Thung Kra Mang. 16° 15' North-101° 30' East, altitude 800 m. Botanical identification: K Larsen.

Fig. 95. Hypericum japonicum Thunb. From: KLU Herbarium 24155. Herbarium Jutlandicum (AAU), Botanisk Institut Aarhus Universitet. Flora of Thailand project, 4th Expedition 1972. Field collectors: Kai Larsen, Supee S Larsen, I Nielsen & T Santisuk. Eastern Thung Kra Mang. 16° 15' North-101° 30' East, altitude 800 m. Botanical identification: K Larsen.

and somewhat very thin,6mmx3mm , ribbed seeds that are 0.5 mm long

OH O

HOHO.

OH O

HOHO.

OH O OH Hypericin

Glu-O

Glu-O

1 5 Dihydroxyxanthone glucoside

OH O OH Hypericin

1 5 Dihydroxyxanthone glucoside

Antiviral properties: Like Hypericum perforatum L. (St. John's Wort), the constituent responsible for the red colour of the juice contained in the dots on the leaves and the flowers of Hypericum japonicum Thunb. is hypericin. This naph-thodianthrone has attracted a great deal of interest on account of its antiretroviral properties, and it has even undergone clinical trials as an anti-HIV drug (Lavie G et a/., 1989). Hypericin is probably responsible for the anti-HSV-II activity observed by Zheng in 1989.

Other properties: The antimicrobial activity of Hypericum japonicum Thunb. is attributed to saroaspidin A, B, and C and sarothralin G (Ishiguro K et al, 1987; 1990). Note that the plant produces xanthones, jacarelhyperols A and B, which inhibit Platelets Activation Factor-induced hypotension in vivo (Ishiguro K etal, 2002), as well as 1-5 dihydroxyxanthone-6-O-^-D-glucoside and iso-jacareubin, which promote and inhibit coagulation in vitro respectively (Wu QL etal, 1998).

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