Melastoma candidum D

[From Greek, me/as = black and stoma = mouth and from Latin, candidus = white]

Physical description: It is a common bush found in Asia. The stems are terete and hairy. Leaves: simple, opposite and

Common name: Sendudukputeh (Malay).

without stipules. The petiole is hairy, channeled and 7 mm-1.8 cm long.The blade is broadly lanceolate, hairy, coriaceous, 9.5 cm x 5.5cm-7cm x 4 cm and marked with 7 longitudinal nerves. The margin is recurved and wavy, and the tertiary nerves are conspicuous below. The inflorescences are terminal and the flowers white. The fruits are hairy and 1.2 cm x 8 mm (Fig. 170).

Pharmaceutical interest: The medicinal properties of Melastoma candidum D. Don are attributed to tannins and flavonoids. Castalagin, procyanidin B-2 and helichryoide, characterized from the leaves of Melastoma can-didum D. Don, lower blood pressure dose-dependently through a decrease of sympathetic tone in spontaneously hypertensive rats (Cheng JT et a/., 1993). Quercitrin, isoquercitrin, rutin, and quercetin, isolated from the leaves of Melastoma candidum D. Don, display free radical scavenging activity and inhibit MAO-B. with IC50 values of 19.06, 11.64, 3.89, and 10.89 ^M respectively (Lee MH etal., 2001).

Procyanidin B - 2

Procyanidin B - 2

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