Treatment Of Neurodegenerative Diseases

The local controlled delivery of neurotrophic factors (e.g. NGF, and glial cell-derived neurotrophic factor, GDNF) can be very advantages for the treatment of neurodegenerative diseases, such as Parkinson's, Huntington's and Alzheimer's Disease. For this purpose, biodegradable controlled release microparticles have been proposed (71,63,79-85). For instance, Pean et al. (82) prepared PLGA-based microparticles loaded with NGF and evaluated their in vivo performance in rat brain. Drug-loaded as well as placebo microparticles were injected near the septal cholinergic neurons, axotomized by an unilateral transection of the fornix-fimbria (Fig. 17A and 17B). The histological analysis 2 and 4 weeks after administration revealed a non-

0 50 100 150 200 250

Figure 16 Novel MEMS for controlled local drug delivery within the brain.

(A) Schematic presentation of the different layers the devices are composed of,

(B) photographs showing the top and bottom sides of an assembled device, (C) in vitro BCNU release into phosphate buffer saline upon activation using a potentiostat (at the time points indicated by the dashed lines). The microreservoirs were filled either with pure drug or with a BCNU:PEG blend (the drug percentage is indicated in the figure). Source: From Ref. 20.

0 50 100 150 200 250

Figure 16 Novel MEMS for controlled local drug delivery within the brain.

(A) Schematic presentation of the different layers the devices are composed of,

(B) photographs showing the top and bottom sides of an assembled device, (C) in vitro BCNU release into phosphate buffer saline upon activation using a potentiostat (at the time points indicated by the dashed lines). The microreservoirs were filled either with pure drug or with a BCNU:PEG blend (the drug percentage is indicated in the figure). Source: From Ref. 20.

□ No microparticle

□ Unloaded microparticles

■ NGF-loaded micropart ides

40" rJm J

Was this article helpful?

0 0
Dealing With Asthma Naturally

Dealing With Asthma Naturally

Do You Suffer From ASTHMA Chronic asthma is a paralyzing, suffocating and socially isolating condition that can cause anxiety that can trigger even more attacks. Before you know it you are caught in a vicious cycle Put an end to the dependence on inhalers, buying expensive prescription drugs and avoidance of allergenic situations and animals. Get control of your life again and Deal With Asthma Naturally

Get My Free Ebook


Post a comment