While the identity of the endocannabinoid(s) involved in retrograde signalling remain to be determined directly, some clues have come from our understanding of the biosynthetic pathways involved in their production and degradation. Below we discuss the mechanisms underlying the postsynaptic production and release ofendocannabinoids in relation to retrograde signalling. Depolarisation and mGluR-induced retrograde signalling are mediated by distinct Ca2+-dependent and -independent intracellular cascades that provide some clues to the endo-cannabinoids involved in these processes. However, many issues remain to be resolved.
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