Classification of Cannabinoid Receptor Ligands

Cannabinoide Ring Ring

Classical cannabinoids CCs are ABC-tricyclic terpenoid compounds bearing a benzopyran moiety Figs. 1-3,5, and 6 . This class includes the natural product - -49-THC 1, Fig. 1 , the more stable and almost equipotent isomer - -48-THC 2, Fig. 1 , and other pharmacologically active constituents of the plant Cannabis sativa. Many CC analogs have been synthesized and evaluated pharmacologically and biochemically for reviews see Goutopoulos and Makriyannis 2002 Khanolkar et al. 2000 Makriyannis and...

Cannabinoids and Thermoregulation

One of the characteristic pharmacological properties of CB1 receptor agonists is an ability to induce hypothermia (Pertwee 1985). The changes of body temperature caused by cannabinoids are dose dependent. According to Pertwee, higher doses of THC cause hypothermia by lowering the thermoregulatory set point, while lower doses are hyperthermic. It has been postulated that differential Gs and Gi protein activation by CB1 receptors could explain these findings (Sulcova et al. 1998)....