How I Healed my Erectile Dysfunction

Mental Impotence Healer Program

Mike Millers Mental Impotence Healer is an eBook that utilizes guided imagery to help you to cure your psychological impotence. In guided imagery, you will be guided into imagining a scenario to help you overcome physical and psychological issues. It commonly uses descriptive language and guidelines that have direct affects on the brain. Because the mind greatly influences your body, this method will help you have rock-hard erections whenever you need them most. Simply listen to The Mental Impotence Healer Program for 2 months and completely annihilate your sexual fears and in next to almost no time you will make yourself a brand new You! Recharged with sexual energy, bursting with self-confidence, strong on command, and conditioned to know that your days of Psychological Impotence are gone, for all time! The Mental Impotence Healer Program gives you your confidence back and will boost your self-esteem to amazing new heights. Listen to the beautiful, calm and relaxing Guided Imagery session and it will totally transform your sex life. You will obtain control over your erections without taking any harmful medication or dangerous pills. Grab a set of headphones and the recordings will go to work while you relax. The carefully mastered binaural beats and subliminal messages will reprogram your subconscious mind to a radically altered state of heightened sexual awareness and desire! Read more...

Mental Impotence Healer Program Summary

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Pfaffia paniculata and ginseng

Ginseng is an ambiguous vernacular term that can refer to Panax species such as Panax ginseng (Asian ginseng) and Panax quinquefolius (American ginseng), Eleutherococcus senticosus (Siberian ginseng), and Pfaffia paniculata (Brazilian ginseng). See ginseng in the monograph on Araliaceae. Asthma occurred in a patient who had been exposed to Pfaffia paniculata root powder used in the manufacturing of Brazil ginseng capsules (1). Airway hyper-reactivity was confirmed by a positive bronchial challenge to metha-choline and sensitivity to the dust was confirmed by immediate skin test reactivity, a positive bronchial challenge (immediate response), and the presence of a specific IgE to an aqueous extract detected by ELISA. The bronchial response was inhibited by sodium cromoglicate. Unexposed subjects did not react to this ginseng extract with any of the tests referred to above. The same study performed with Korean ginseng (Panax ginseng) was negative.

Ginseng and Erectile Function

Erectile dysfunction is commonly associated with diabetes, a condition that has well-characterized effects on peripheral tissue innervation and vascularization 21 . Penile intracavernous pressure after nerve stimulation was significantly lower in long-term diabetic rats relative to age-matched controls 22 . In diabetic rats treated with Korean red ginseng (30 mg kg-1) for one month, however, erectile function was not different from nondiabetic age-matched controls 22 . Ginseng use has also been shown to produce beneficial effects in clinical studies (Table 4.1) that evalu- Control g Ginseng Fig. 4.2 Ginseng treatment enhances copulatory behaviors in male rats. Animals were treated daily with either a sesame oil vehicle (control) or 100 mg kg-1 Panax quinquefolius for 28 d. When placed with sexually receptive female rats, latency (in seconds) to mount (ML), intromit (IL), and ejaculate (EL) were determined. * p 0.05 relative to control. (Figure adapted from 20 ) ated the efficacy of...

Central Nervous System Actions of Ginseng

Besides the potential direct effects of ginseng ginsenosides on penile nerve and vascular tissues, ginsenosides may also exert actions on the brain to modulate neurotransmission. Ginsenosides, notably Rb1, Rc, Rg1, and Rg3, facilitate acetylcholine activity 43, 44 , are neuroprotective 45-48 , and alter neurotransmitter availability 49-52 . The neurotransmitter dopamine plays a central role in sexual behav ior 53, 54 , and treatment with dopaminergic drugs has long been shown to facilitate masculine sexual behavior 55, 56 . In the paraventricular nuclei (PVN) and medial preoptic area of the hypothalamus (MPOA), brain areas critical for male sexual behavior 57 , dopamine levels are increased before and during copulation 58, 59 . The microinjection of dopamine receptor antagonists directly into the MPOA decreases libido and impairs copulatory performance 60, 61 . NO may be an important mediator of hypothalamic dopamine release 62 . Treatment with NOS inhibitors decreased hypothalamic...

Herbal Treatments for Erectile Dysfunction

Abstract Evidence for herbal treatments for ED is contradictory. This could be due to differing definitions of ED, non-standardized outcomes and different procedures used in the preparation of plant extracts. Additionally, animal studies are not accurate because they do not allow cerebral aspects of sex to be evaluated and instead rely solely on basic mechanical or instinctive sexual function. Preliminary research on a few drugs such as ginseng, PLC and DHEA is encouraging, but well-designed randomized controlled clinical trials are lacking. It is likely that the use of medicinal plants will increase in popularity as men seek subtle methods of treating themselves. However, whilst it is easy to purchase many 'natural Viagra'-like substances over the Internet, the safety and reliability of many of these drugs is poor, and patients should be cautious when acquiring these products. Information about how these herbal products interact with prescribed drugs is also limited. Keywords...

Interactions Of Ginseng With Drugs

Ginseng is a widely used herbal product in China, other Asian countries and also in the United States. For thousands of years, the common people in China have used ginseng as a tonic. The Chinese ginseng that grows in Manchuria is Panax ginseng. However, the ginseng that grows in North America is Panax quinquefolius. The common preparation of ginseng is ginseng root. Ginseng is promoted as a tonic and also as a reliever of stress. Ginseng may also be effective in the treatment of mild hyperglycemia. In Germany, it is indicated to combat lack of energy. Ginseng contains saponins known as ginsenosides. Lee et al. studied interaction between P. ginseng and alcohol in 14 healthy male volunteers utilizing each subject as their own control. At 40 min after the last drink, the blood alcohol in the test group receiving ginseng extract (3 gm 65 kg bodyweight) along with alcohol (72 g 65 kg bodyweight) was about 35 lower than the control value (75). A study using mice indicated that decreased...

Herbal Alert Ginseng

Ginseng has been called the king of herbs because of its wide use and the benefits attributed to the herb. In early times in China, ginseng was valued as high as gold. Hundreds of ginseng products (eg, gum, teas, chewing gum, juices) are sold throughout the US. Ginseng is the fourth best selling herb in the US. The primary use ofginseng is to improve energy and mental performance. The benefits of ginseng include improving endurance during exercise, reducing fatigue, boosting stamina and reaction times, and increasing feelings of well-being. Adverse reactions are rare, but sleeplessness, nervousness, and diarrhea have been reported in individuals taking large amounts of the herb. The herb should not be taken in combination with stimulants including those containing caffeine. Dosage is 200 to 500 mg day of the standardized extract or 1 to 4 g of powdered root a day. Ginseng is contraindicated in individuals with high blood pressure and during pregnancy.

Organs and Systems Sexual function

Intracavernous administration of papaverine with phen-tolamine has been used in the diagnosis and treatment of erectile dysfunction. The major local adverse effect is prolonged erection, which usually occurs early during diagnostic testing and is reduced after dose adjustment furthermore, local hematomas have been reported in a number of patients. It may be that patients most susceptible to priapism can be identified in advance by testing their erectile abilities in response to erotic stimulation (1). Long-term therapy can also cause intracavernous fibrosis but it can also lead to development of tolerance to the desired effect.

Family Araliaceae A L de Jussieu 1789 nom conserv the Ginseng Family

Pharmaceutical interest To the family Araliaceae belong Panax ginseng C. A. Meyer (ginseng) Panax quinquefolium L. (American ginseng) Panaxnotogin-seng Burk. (san-chi ginseng) Panaxpseudoginseng Wall. species Japonicus Hara Panax japonicus CA Meyer (Japanese or chikusetsu ginseng) Panax pseudoginseng Wall. species himalaicus (Himalayan ginseng) and Eleuthe-rococcus senticosus Maxim Acanthopanax senticosus (Siberian ginseng), which are all routinely used to invigorate the body and as a cure-all and universal remedy for panacea (Greek navatce remedy from where Panax) by millions of peoples since ancient times. Examples of ornamental Araliaceae are Hedera helix L. (common ivy), Schefflera species and Polyscias species. In the Asia-Pacific, about 50 species of the plants species classified within the family Araliaceae are medicinal. Note that most of these plants are used to counteract putrefaction, combat fever, promote expectoration and invigorate the body.

Panax ginseng C A Meyer

Meyer or ginseng, Korean ginseng jen shen, shen ts'ao, t'u-ching (Chinese). Ginseng is used to invigorate the body, treat flatulence, soothe inflammation, stimulate venereal desire, calm the mind and fight forgetfulness. Many products containing ginseng are available, especially for the symptomatic treatment of functional asthenia (Pharmaton ). Ginseng is incorporated in the B. H. P. (1990) and in the British Herbal Compendium (Vol. 1, 1992). Pharmaceutical potential The medicinal properties of Panax ginseng C. A. Meyer result principally from the synergistic effect of 3 types of natural products triterpenoid saponins, poly-acetylenes fatty acids and polysaccha-rides. Uses Ginseng is said to have been used as a medicine in China and Tibet since ancient times (2000 B. C.-3000 B. C.). Its use was formerly reserved for emperors, their households and conferred by imperial favor upon high and useful officers. The plant was collected at night, as the berries...

Siberian Ginseng Asian Ginseng and Ashwagandha

There is one case report of interference of Siberian ginseng in serum digoxin measurement. A 74-year-old man had a steady serum digoxin level of 0.9-2.2 ng mL for 10 years. His serum digoxin increased to 5.2 ng mL on one occasion after taking Siberian ginseng. Although the level was toxic, the patient did not experience any sign or symptoms of digoxin toxicity. The patient stopped taking Siberian ginseng, and his digoxin level returned to normal (106). However, in our experience, Siberian ginseng only has a very modest interference with the FPIA and most digoxin assays we tested had no effect at all (107). Therefore, in the case report, it is possible that the patient ingested some other herbal remedy mislabeled as Siberian ginseng. Mislabeling of Chinese herbs has been previously reported. Asian ginseng, which is prepared from a different herb than Siberian ginseng, also showed modest interference with the FPIA but other digoxin immunoassays were not affected at all (107). More...

Introduction to Ginseng

Ginseng most commonly refers to the plant Panax ginseng C.A. Meyer (Asian ginseng) or Panax quinquefolius L. (North American ginseng). Ginseng is widely used in Asian countries as a tonic to promote and maintain good health, and as a constituent in herbal medicines used to treat various diseases, including liver dysfunction, hypertension, cerebrovascular disease, atherosclerosis, cancer, postmenopausal symptoms, and impotence 1-8 . Elsewhere, ginseng supplements are marketed as a natural stimulant that will increase endurance and vitality and improve overall health. It is the root of the ginseng plant that is harvested for its reported medicinal effects. The root is typically dried (white ginseng) or steamed (red ginseng) and can also be extracted to concentrate its bioactive components, the ginsenosides. Ginsenosides are unique to ginseng and are saponin glycosides containing one or more sugar moieties that form side chains off the aglycone ginsenoside structure 9 . There are over 20...

Physiology of an Erection

Impotence, or erectile dysfunction, can be defined as the persistent inability to develop and or maintain an erection adequate for sexual intercourse. Vascular diseases, including atherosclerosis, hypertension, diabetes, and high cholesterol, can cause restricted blood flow to the penis and may account for approximately 70 of physically related causes of erectile dysfunction 11 . The arterial blood supply to the penis is mainly provided by the internal pudendal artery, which branches into several smaller arteries that contribute to vascularization of the erectile tissues. The erectile tissue of the human penis consists of two dorsal corpora cavernosa and a ventral corpus spongiosum. Reduced sympathetic input combined with stimulation Fig. 4.1 Chemical structure of ginsenoside Rg1, a classical protopanaxatriol found in both Panax ginseng and Panax quinquefolius Fig. 4.1 Chemical structure of ginsenoside Rg1, a classical protopanaxatriol found in both Panax ginseng and Panax...

Ginseng and Male Sexual Behavior

Abstract Ginseng is widely used in Asian countries as a tonic to promote and maintain good health and as a constituent in herbal medicines used to treat various diseases, including liver dysfunction, hypertension, cerebrovascular disease, atherosclerosis, cancer, postmenopausal symptoms, and impotence. Very few controlled clinical studies have been performed to validate the medicinal use of ginseng or its constituents in humans. However, laboratory studies, primarily using rodents, have elucidated potential medical uses for ginseng and ginsenosides in the treatment of a number of human disorders, including impotence and loss of libido. Panax ginseng and Panax quinquefolius have both been shown to enhance male cop-ulatory behavior in laboratory studies. Human studies have suggested that ginseng ingestion may be a safe and effective alternative method for treatment of erectile dysfunction. Ginsenosides have been shown to interact with steroid receptors and, through nongenomic pathways,...

Ginseng and Copulatory Behavior Animal Studies

Panax ginseng and Panax quinquefolius have both been shown to enhance male copulatory behavior in laboratory studies (Table 4.1) 18-20 . Copulatory behavior can be examined in male rodents by placing them with sexually receptive female conspecifics and measuring the following parameters mount latency time from introduction of the female until the first mount with pelvic thrusting intromission latency time from introduction of the female until first mount with pelvic thrusting and vaginal penetration ejaculation latency time from the first intromission until ejaculation and postejaculatory interval or the refractory period time from ejaculation until next intromission. A reduced latency to mount the female would indicate increased male sexual arousal, whereas a decreased latency to intromit or ejaculate would be indicative of increased copulatory performance. In male mice whose normal copulatory behavior was compromised as a result of prolonged individual housing, the daily...

Sexual function

Intracavernosal alprostadil was effective and well tolerated in the treatment of erectile dysfunction, according to the results of a 6-month study (funded by Pharmacia & Upjohn) in 848 men (mean age 52 years) with at least a 4-month history of erectile dysfunction (10). This is provided that the individual dose is established by titration and patients receive training in injection techniques and periodic supervision during treatment. An initial dose was established for each patient and the patients then administered the alprostadil themselves at home. Of 727 evaluable patients, 682 (94 ) had at least one erectile response after the injection of alpros-tadil, and 88 of injections lead to a satisfactory sexual response. The most commonly reported adverse event was penile pain, reported by 44 of patients, but only after 8 of injections. In just over half of the patients who had penile pain, the condition was reported as mild. There is a high dropout rate from self-injection therapy for...

Sildenafil

Myocardial infarction has been attributed to the combination of cannabis and sildenafil. A 41-year-old man developed chest tightness radiating down both arms (107). He had taken sildenafil and cannabis recreationally the night before. His vital signs were normal and he had no signs of heart failure. However, electrocardiography showed an inferior evolving non-Q-wave myocardial infarct and his creatine kinase activity was raised (431 U l). Cannabis inhibits CYP3A4, which is primarily responsible for the metabolism of sildenafil, increased concentrations of which may have caused this cardiac event.

Panax ginseng

Meyer (Araliaceae), usually 4 to 6 years after cultivation, has been used as a general tonic or adaptogen and is frequently featured in TEM prescriptions. Many studies have validated the empirical usage of ginseng over thousands of years for gi-invigorating and cardiovascular effects in TEM. The main active components of P. ginseng are ginsenosides, which have been shown to have a variety of beneficial effects, including anti-inflammatory, antioxidant, and anticancer effects 14 . P. notoginseng, from the same genus as P. ginseng, and its saponins exert a protective effect on ischemic brain damage in vivo 15, 16 and focal cerebral ischemia 17, 18 . Ginseng has neuroprotective effects in transient focal or global cerebral ischemia 19-21 . Red ginseng powder, which is steamed ginseng under pressure, also prevents delayed neuronal death in gerbils. Ginsenoside Rb1 (Fig. 16.1) protects the brain from reversible focal brain ischemia in rats 22 and protects...

Herbal Therapy And Nutritional Supplements

Botanical medicine or herbal therapy is a type of complementary alternative therapy that uses plants or herbs to treat various disorders. Individuals worldwide use both herbal therapy and nutritional supplements extensively. According to the World Health Organization (WHO), 80 of the world's population relies on herbs for a substantial part of their health care. Herbs have been used by virtually every culture in the world throughout history, from the beginning of time until now. For example, Hippocrates prescribed St. Johns Wort, currently a popular herbal remedy for depression. Native Americans used plants such as coneflower, ginseng, and ginger for therapeutic purposes. Herbal therapy is part of a group of nontraditional therapies commonly known as complementary alternative medicine (CAM). Unfortunately, CAM therapies are not widely taught in medical schools. A 1998 survey revealed that 75 of 117 US medical schools offered elective courses in CAM or included CAM topics in required...

Drug Drug Interactions SSRIs

Amfebutamone is sometimes used to augment the action of other antidepressant drugs, but there are few data on the pharmacokinetic effects of this strategy. In an open study in 19 consecutive patients (7 men and 12 women), amfebutamone (150 mg day for 8 weeks) did not alter plasma concentrations of paroxetine or fluoxetine (21). Plasma concentrations of venlafaxine increased, but concentrations of its active metabolite, O-desmethylvenlafaxine, fell. Overall tolerability was good and there was a significant reduction in depression rating scales. Sexual function, particularly orgasmic function in women, improved. These data suggest that adding amfebutamone to SSRI treatment does not alter plasma concentrations of SSRIs. The addition of amfebutamone to venlafaxine seems unlikely to cause pharmacokinetic problems in practice, because the increase in plasma concentration of the parent compound was offset by a reduction in the concentration of its major active metabolite. However, there is...

Drug Administration Drug formulations

Intramuscular testosterone is given as a deep intramuscular injection of single testosterone esters or a mixture of testosterone propionate, testosterone phenylpropionate, testosterone isocaproate, and testosterone decanoate (Sustanon), every 2-3 weeks. In one series of 551 injections, 162 were associated with pain and bleeding injection in the gluteal site caused fewer complaints and was less susceptible to bleeding, but was painful more often than injection in the deltoid muscle or thigh (66). There were no serious adverse effects and the only systemic adverse effect was episodes of sudden non-productive cough associated with faintness after eight injections which the authors thought might have been due to pulmonary oil microembolism. Systemic availability of testosterone after intramuscular administration is variable and there can be fluctuations in mood and sexual function (67). High testosterone concentrations can cause raised lipid concentrations (68).

Endocrine and Sexual Effects

All standard antipsychotic drugs elevate serum prolactin levels by blocking the tonic inhibitory actions of dopamine on lactotrophic cells in the pituitary. Among second-generation antipsychotics, risperidone and amisulpride can produce dose-dependent hyperprolactinemia to a greater extent than firstgeneration antipsychotics, whereas clozapine, olanzapine, ziprasidone, and quetiapine do not cause a sustained elevation of prolactin above normal levels. Aripiprazole, being a partial DA agonist, produces no elevation of prolactin and even suppresses prolactin levels slightly. Hyperprolactinemia in women can lead to menstrual disturbances, including anovu-latory cycles and infertility, menses with abnormal luteal phases, or frank amenorrhea and hypoestrogenemia. Women have also reported decreased libido and anorgasmia, and there are reports of increased long-term risk of osteoporosis although this is controversial. Antipsychotic-induced gyneco-mastia has been reported in 3 of women and 6...

Treatment Options for Depression

Selective Serotonin Reuptake Inhibitors (SSRIs) Named for their action in the brain, SSRIs have proved to be enormously helpful for depression. They need to be taken every day and take some weeks to become effective. Their side effects are minimal in most people, although some people experience fatigue and a few become agitated. Most people notice decreased sexual drive and impaired sexual response, side effects that can cause considerable distress. Monamine Oxidase Inhibitors (MAOIs) Named for their action in the brain, MAOIs are also very effective. They too must be taken every day and take weeks to become effective. Common side effects include weight gain, dry mouth, insomnia, impaired sexual response, and low blood pressure. Their most troubling side effect is the potential to cause a stroke if you ingest adrenaline or adrenaline-like substances. MAOIs can be used only with a fairly strict diet that avoids foods or medicines that contain adrenaline or adrenaline-like substances....

W Hemp Chronicles

Meanwhile, to add further confusion, the 1980s brought forth the medicinal argument to the broader discussion of cannabis prohibition in North America. Not only were expert opinions about the health impacts of cannabis contradictory, but here we see also the emergence of a group with the belief that this much-maligned drug can actually be therapeutic. It's not really a new belief cannabis has been used by herbalists for millennia and has been proscribed for everything from failing eyesight to erectile dysfunction (Spicer 2002). In fact, cannabis even existed in the pharmacopoeia of the U.S. from 1850 until 1942. Statements by various government officials seem to back this up in 1988, U.S. Drug Enforcement Agency (DEA) administrative law judge Francis L. Young noted that in its natural form, cannabis is one of the safest therapeutically active substances known, and the 1972 Canadian Le Dain commission reached similar conclusions (Young 1988 LeDain 1972). Further, the 1978 creation of...

Weight Loss the Natural

Many over-the-counter treatments are herbal supplements popularized by the recent trend toward all things natural. In a grocery or department store, a shopper can buy a vast array of different herbal supplements, all reported to have some healing property or nutritional value. Ginseng, echinacea, ginger root, flaxseed oil, lavender oil, and shark cartilage are all examples of the things one can find, each with a different function that supposedly makes life better.

Pituitaryadrenal axis

Syndrome, the predominant symptoms are in part determined by hyperandrogenicity and tend to comprise hypertension, acne, impaired sight, disorders of sexual function, hirsutism or virilism, striae of the skin, and plethora, Cushing's syndrome due to glucocorticoid therapy is likely to cause benign intracranial hypertension, glaucoma, subcapsular cataract, pancreatitis, aseptic necrosis of the bones, and panniculitis. Obesity, facial rounding, psychiatric symptoms, edema, and delayed wound healing are common to these different forms of Cushing's syndrome.

Its getting harder every day

When Viagra hit the market in 1998, a few women's health advocates mistakenly cried foul at the notion that drug companies were creating drugs to deal with male sexual dysfunction but not women's. Further, they reiterated the claims that our sexist culture still has not come up with a male birth control pill because men are not willing to take responsibility for contraception. In fact, Viagra was discovered by accident in a clinical trial for a drug intended to treat angina. Men in the trial were reporting a surprising and sometimes awkward side-effect that in some cases improved some aspects of their I don't know about you, but I don't know many men that wouldn't opt to take a pill to prevent unintentional fatherhood responsibilities. If we count on men being as shallow as we think they are (a safe bet), you would have men bragging about being on the pill. Also, the accusations of no effort going into male contraceptives miss the minor detail that there has actually been a lot of...

General adverse effects

Men taking estrogens generally do so in the course of palliative treatment for malignancies (prostatic carcinoma), for which high doses have sometimes been used. Estrogen therapy in men with prostate cancer may be superior to castration in terms of efficacy, but orally administered estrogens are associated with adverse effects gynecomastia, loss of sexual function, and unacceptable cardiovascular toxicity (9). Low-dose estrogens in combination with anti-androgens or antithrombotic agents may be better tolerated.

How to Monitor Your Progress

Changes in your condition will affect your relationship with your family, friends and, most especially, your partner. Ideally, these will be positive changes that will enhance your relationships. Sometimes however, these changes can require unforeseen adjustments. For example, if sildenafil (Viagra) improves your sexual functioning, the change may be disconcerting to someone who has grown accustomed to your previous level of sexual interest. If fluoxetine has improved your anxiety and depression to the point that you want to start working, your partner' s

How to Stop Medication

Drug Holidays There are times when it makes sense to stop the medications on a regular basis for brief periods. For example, some children with ADHD take methylphenidate only on school days, not on weekends or during vacation. This minimizes the retarding effect methylphenidate can have on growth. Some people find that omitting one or two doses of their antidepressant improves the impairment the drug causes to their sexual functioning. A drug holiday needs to take the above issues into account, however, and should never be undertaken without consulting with your doctor.

Herbal Alert Warfarin Interaction

Warfarin, a drug with a narrow therapeutic index, has the potential to interact with many herbal remedies. For example, warfarin should not be combined with any of the following herbs because they may have additive or synergistic activity and increase the risk for bleeding celery, chamomile, clove, dong quai, feverfew, garlic, ginger, ginkgo biloba, ginseng, green tea, onion, passion flower, red clover, St. John's wort, and tumeric. Any herbal remedy should be used with caution in patients taking warfarin.

Clinical Use Of Agents

Remains to be seen whether selective prostanoid receptor antagonists might provide better medicines for the treatment of pain and other therapeutic indications. A summary of the available agents and their indications is presented in Table 6.13. The therapeutic areas in which these agents are used are diverse and are a consequence of the widespread physiological actions of the natural prostaglandins. Prostaglandins used in the termination of pregnancy, cervical ripening, and labor induction include dinoprost (PGF2a) and carbaprost (15-methyl-PGF,,), dinoprostone (PGE2), sul-prostone,gemeprost, and misoprostol. Alpros-tadil (PGEi) is used to treat erectile dysfunction. Prostaglandins used in cardiovascular conditions include alprostadil and the PGE, analog, limaprost, as well as epoprostenol (prostacyclin) and its analog, iloprost. Miso-prostol is used clinically, with some success, as an inhibitor of gastric acid secretion. Prosta-glandins, particularly of the F series, are widely used...

Comparative studies

Adverse effects and quality of life have been compared in 431 men with prostate cancer treated with a gonador-elin agonist or orchidectomy (3). Of the men who reported normal sexual function before treatment, 51 had reduced libido and 69 became impotent. Of those given gonadorelin, 57 had hot flushes. Breast swelling was more common in those given gonadorelin (25 compared with 10 after orchidectomy).

Impact on Therapeutic Drug Monitoring

Interactions of Ginseng with Drugs Interactions between herbal supplements and drugs and between food and drugs are of significant clinical importance. St. John's wort, a popular herbal supplement, induces cytochrome P 450 mixed function oxidase as well as modulated P-glycoprotein in intestine and reduces plasma concentrations of cyclosporine, tacrolimus, amitriptyline, digoxin, fexofenadine, indinavir, methadone, midazolam, nevirapine, phenoprocoumon, squinavir, simvastatin, theophylline and warfarin. These reductions may cause treatment failures. Interaction of warfarin with herbal supplements may increase or decrease the anticoagulant effect of warfarin. Important interactions of various drugs with ginseng, ginkgo biloba, kava and garlic have also been reported. Consumption of a single glass of grapefruit juice caused a twofold to threefold increase in the plasma concentration of felodipine, and pharmocokinetics of approximately 40 other drugs are also affected by intake of...

General Information

Of the many possible formulations tested all have proved to have unacceptable facets, generally including a very slow onset of action, uncertain reliability, and undesirable effects on biochemistry, body weight, or sexual function. However, some progress has been made with the combination of oral desogestrel and intramuscular testosterone.

Interaction Of Warfarin With Herbal Supplements

Warfarin acts by antagonizing the cofactor function of vitamin K. Variability in the anticoagulant response to warfarin is an ongoing clinical dilemma. Although clinical efficacy of warfarin varies with intake of vitamin K, genetic polymorphisms that modulate expression of CYP2C9, the isoform mediating clearance of S-warfarin, may have significant effect on warfarin therapy. Moreover, several herbal remedies also interact with warfarin. St. John's wort may have the potential to diminish warfarin's anticoagulation effect by increasing clearance through inducing CYP2C9 (66). Another report indicates that St. John's wort increases clearance of both R- and S-warfarin but ginseng has no effect (67).

Overall level of evidence for adverse effects B

Sexual function questionnaire Prevalence of erectile dysfunction as compared with men without cardiac diseases 7 reporting no erectile dysfunction, 17 reporting erectile dysfunction No 22208 Rosen RC, Fisher WA, Eardley I, Niederberger C, Nadel A, Sand M. Men's Attitudes to Life Events and Sexuality (MALES) Study. The multinational Men's Attitudes to Life Events and Sexuality (MALES) study I. Prevalence of erectile dysfunction and related health concerns in the general population. Curr Med Res Opin. 2004 May 20(5) 607-17. English Erectile dysfunction Sexual function questionnaire 2218 Blumentals WA, Gomez-Caminero A, Joo S, Vannappagari V. Should erectile dysfunction be considered as a marker for acute myocardial infarction Results from a retrospective cohort study. Int J Impot Res. 2004 Aug 16(4) 350-3. English Prevalence of erectile dysfunction as compared with men without cardiac diseases OR 3.13 (95 CI 2.35-4.16) No 22206 Grover SA, Lowensteyn I, Kaouache M, Marchand S, Coupal L,...

Overall level of evidence of adverse effects D

Quantification Sexual function scale hormones Sexual function, depressed testosterone level, decreased Erectile function 6 21381 Gupta S, Salimpour P, Saenz de Tejada I, Daley J, Gholami S, Daller M, Krane RJ, Traish AM, Goldstein I. A possible mechanism for alteration of human erectile function by digoxin inhibition of corpus cavernosum sodium potassium adenosine triphosphatase activity. J Urol. 1998 May 159(5) 1529-36. English Cardiac disease Erectile function Erectile function, impairment No influence on libido and testosterone Complete impotence Erectile dysfunction

Betablocker Medications

Beta-blockers may be useful for individuals who have situa-tional anxiety or performance anxiety. They generally have not been effective in treating anxiety disorders such as generalized social anxiety disorder, panic disorder, or obsessive-compulsive disorder. These medicines are most useful for treatment of anxiety syndromes and disorders with somatic symptoms associated with increased adrenergic tone. Propranolol in doses of 10 to 40 mg day has been used for performance anxiety, on an as-needed basis. Recent research on PTSD suggests a different role for the beta-blocker medications. It appears that traumatic memories may be reduced by medications that

Male Sex Hormones and Anabolic Steroids

Androgenic steroids are used in medicine for replacement therapy in men with insufficient function of the male sex glands, for maturation arrest, impotency, climacteric, and other irregularities, and in women for breast and ovarian cancer and climacteric disorders. Like all steroid drugs, androgens are functionalized derivatives of cyclopentanophenan-threne.

Pregnancy Category X

Methyltestosterone is a synthetic drug manufactured from testosterone. Methyltestosterone's medical uses include supplementation of testosterone in males with low levels of that hormone and treatment of female breast cancer. Scientists report unsatisfactory results from a test of whether the compound might work as a male contraceptive and mixed results when the substance was used to treat male impotence. Impotence improvement was better when methyltestosterone was taken in combination with a yohimbe preparation. Methyltestosterone has provided pain relief and occasionally fertility enhancement to women suffering from a reproductive disorder called endo-metriosis externa. Therapeutic regimens to build up bone strength in older women may include methyltestosterone, as may therapies designed to compensate for hormonal changes caused by menopause. In research projects height increase occurred when the drug was administered to boys of short stature. Experimenters describe the drug as...

Treatment consequences Efficacy Side effects compromising effectiveness Randomization of patients Dose arms 13 Study

Erectile dysfunction Erectile function 1547 Waldhauser M, Schramek P. Efficiency and side effects of prostaglandin E1 in the treatment of erectile dysfunction. J Urol. 1988 Sep 140(3) 525-7. English Erectile dysfunction Erectile function Erectile function, improvement 1052 Becher E. Topical alprostadil cream for the treatment of erectile dysfunction. Expert Opin Pharmacother. 2004 Mar 5(3) 623-32. English Erectile dysfunction Erectile function 21514 Purvis K, Brekke I, Christiansen E. Determinants of satisfactory rigidity after intracavernosal injection with prostaglandin E1 in men with erectile failure. Int J Impot Res. 1996 Mar 8(1) 9-16. English

Physiology and Pharmacology

Erection occurs as a result of increased pressure in the corpora cavernosa, which translates into penile rigidity. The pressure increase is caused by three synergistic processes (2) relaxation of the smooth muscles of the corpora cavernosa (2)increase in arterial blood flow to the penis and (3) restriction of the venous blood flow out of the penis. Both central and peripheral mechanisms contribute to the process of penile erection. At the central level, the psychological component of penile erection is controlled by the hypotha-lamic and limbic systems (140). At the peripheral level, both sympathetic and parasympa-thetic pathways as well as several mediators are involved. Psychogenic and local stimulation results in the release of neurotransmit-ters from the cavernosal nerve terminals and smooth muscle endothelium. Factors that mediate the corpus cavernosum relaxation include nitric oxide (NO), vasoactive intestinal peptide (VIP), calcitonin gene-related peptide and prostaglandin....

Study quality Reference

Erectile dysfunction Erectile function 11489 Lammers PI, Rubio-Aurioles E, Castell R, Castaneda J, Ponce de Leon R, Hurley D, Lipezker M, Loehr LA, Lowrey F. Combination therapy for erectile dysfunction a randomized, double blind, unblinded active-controlled, cross-over study of the pharmacodynamics and safety of combined oral formulations of apomorphine hydrochloride, phentolamine mesylate and papaverine hydrochloride in men with moderate to severe erectile dysfunction. Int J Impot Res. 2002 Feb 14(1) 54-9. English Erectile dysfunction Erectile function Erectile function, improvement 1483 Shamloul R, Atteya A, Elnashaar A, Gadallah A, Zohdy W, Abdelsalam W. Intracavernous sodium nitroprusside (SNP) versus papaverine phentolamine in erectile dysfunction a comparative study of short-term efficacy and side-effects. J Sex Med. 2005 Jan 2(1) 117-20. Erectile dysfunction Erectile function

No of patients treated

Erectile dysfunction in spinal cord lesion Erectile function Papaverine nitrogylcerin 21509 Renganathan R, Suranjan B, Kurien T. Comparison of transdermal nitroglycerin and intracavernous injection of papaverine in the treatment of erectile dysfunction in patients with spinal cord lesions. Spinal Cord. 1997 Feb 35(2) 99-103. English

Herbal Alert Larginine

L-arginine is commonly sold in health food specialty shops as a supplement capable of improving vascular health and sexual function in men. The herb may be beneficial in improving health in individuals with congestive heart failure, peripheral artery disease, angina, hypertension, hyperlipidemia, and type 2 diabetes. The herb appears to increase nitric oxide concentrations. Abnormalities of the vascular endothelial cells may cause vasoconstriction, inflammation, and thrombolytic activity. These abnormalities are partially attributable to degradation of nitric oxide. L-arginine's ability to increase nitric oxide is the basis for its effectiveness in improving some vascular disease states. Oral doses of 9 to 30 g per day are well tolerated. No adverse reactions were reported in those taking 9 g d. Higher doses may cause nausea and mild diarrhea. L-arginine may exacerbate sickle cell crisis and should be used with caution in those with sickle cell anemia.

The Endocannabinoid System and Female Reproductive Function

THC has been reported to account for the majority of the reproductive hazards of marijuana use, and in males it leads to impotence by suppressing spermato-genesis, reducing the weight of reproductive organs, and decreasing the plasma concentration of circulating hormones like testosterone (Kolodney et al. 1974). In

Side effects compromising effectiveness Randomization of patients Dose arms 13 Study quality

Erectile dysfunction in various conditions IIEF Erectile function, improvement Patients' abilities to achieve and maintain an erection in the sildenafil group was significantly improved compared with the placebo group. Mild to moderate in 27 of patients in sildenafil group, and in 8 of patients in placebo group Sildenafil placebo 1208 Meuleman E, Cuzin B, Opsomer RJ, Hartmann U, Bailey MJ, Maytom MC, Smith MD, Osterloh IH. A dose-escalation study to assess the efficacy and safety of sildenafil citrate in men with erectile dysfunction. BJU Int. 2001 Jan 87(1) 75-81. English Sildenafil (G04BE03) Erectile dysfunction IIEF Erectile function, improvement Compared with placebo, sildenafil significantly improved self-esteem, confidence, sexual relationship satisfaction and overall relationship satisfaction. Not mentioned Sildenafil placebo 1 + 1229 Althof SE, O'leary MP, Cappelleri JC, Hvidsten K, Stecher VJ, Glina S, King R, Siegel RL. International SEAR Study Group. Sildenafil citrate...

Prostaglandins in urology

A single dose of PGEi into the corpus cavernosum is highly effective in inducing artificial penile erection in cases of erectile dysfunction. The reported adverse effects include pain and a burning sensation, prolonged penile erection, and local fibrosis. The incidence of pain was high (75 ) in older studies (53), while later data improved to 13-44 (54-57). Pain is cited as a prominent factor in non-adherence to therapy and in the dropout rate of patients from self-injection programs, although the incidence may fall with time (57). An alprostadil sterile powder formulation had a lower incidence of pain after penile injection (6.6 ), attributed to lower doses and the lack of alcohol in the formulation (58). Burning and pain can be reduced by using a lower initial dose, with incremental increases until a satisfactory erection is produced (59).

Randomization of patients Dose arms 13 Study quality Reference

Erectile dysfunction IIEF Significantly better effect of tadalafil regardless of concomitant thiazide use Tadalafil headache 15 dyspepsia 8 back pain 5.3 . Placebo headache 4.0 , dyspepsia 0.7 and back pain 1.2 no statistically significant difference between thiazide users and non-users. Yes Tadalafil placebo 1 - (meta-analysis) 1559 Kloner RA, Sadovsky R, Johnson EG, Mo D, Ahuja S. Efficacy of tadalafil in the treatment of erectile dysfunction in hypertensive men on concomitant thiazide diuretic therapy. Int J Impot Res. 2005 Sep-Oct 17(5) 450-4. 2.4 Drugs Which Compromise Erectile Function 517 Tadalafil (G04BE08) Erectile dysfunction in diabetes mellitus Erectile function, improvement Diabetes group receiving tadalafil 20 mg a mean improvement of 7.4 in the IIEF score against baseline versus 0.9 for placebo 53 of the attempts at intercourse were successful, compared with 22 for placebo Tadalafil placebo 1216 Fonseca V, Seftel A, Denne J, Fredlund P. Impact of diabetes mellitus on...

Organs and Systems Cardiovascular

In several reviews, in which the same data have been analysed, sildenafil has been rated as being well tolerated One patient without a history of previous chest pain or risk factors for cardiovascular disease, developed a well-documented myocardial infarction 30 minutes after he took sildenafil 50 mg and before any attempt at sexual intercourse (8). The interpretation of these sporadic cases is controversial, although some have argued that the reported cardiovascular adverse effects occur more often with sildenafil than with other pharmacological treatments of erectile dysfunction. It is at present unclear whether there is an increased risk with sildenafil. For example, in placebo-controlled trials there have been no differences in the incidences of myocardial infarction, angina, or coronary artery disorders between sildenafil and placebo (9). Exclusion criteria in clinical trials may have prevented the inclusion of patients who are at increased risk of adverse events. On the other...

Long Term Effects Drug tolerance

Potential tachyphylaxis with long-term use of silde-nafil has been discussed following a survey in which 200 patients were questioned twice, 2 years apart, about the effects of sildenafil on the second occasion 20 of them reported needing an increased dose, and 17 had discontinued therapy because of lack of effect (36). However, others have commented that more likely reasons for the loss of effect over time included worsening of the disease (37-41), reducing testosterone concentrations with age (38,39), or lack of proper arousal (42). Although the mRNA for phosphodiesterase type 5 is down-regulated in the retina by long-term administration of sildenafil in rats (43), it is not known whether that happens in human corpus cavernosum, nor whether long-term sildenafil use is associated with tachyphylaxis.

Drug Drug Interactions Calcium channel blockers

Retrospective analysis of clinical trials has suggested that the concomitant use of antihypertensive drugs did not lead to an increase in adverse events in patients also taking sildenafil (45). Hypertensive patients taking amlodipine, in contrast to glyceryl trinitrate, had only a minor supplementary fall in blood pressure when challenged with a single dose of sildenafil, and a few had a mild to moderate headache (46).

Congestive Heart Failure

A number of adverse reactions can occur such as dehydration this is a common risk in the use of all diuretics especially in the elderly patients. Other effects include hypokalemia (usually mild), hyperuricemia gout, impaired glucose tolerance diabetes mellitus, insulin resistance (significance is uncertain), Hypercholesterolemia (usually in short-term therapy rather than in long-term therapy), impotence, and hypercalcemia. Contraindications are gout, diabetes mellitus, and renal disease.

Side effects compromising effectiveness Randomization of patients Dose arms 13 Study quality Reference

Erectile dysfunction IIEF Erectile function, improvement Mean erectile function domain scores of IIEF statistically greater than placebo, irrespective of aetiology, baseline severity or age. Vardenafil significantly improved the IIEF domain scores of erectile function, orgasmic function and intercourse satisfaction. Vardenafil placebo

Overall level of evidence of adverse effects C

Incidence of erectile dysfunction 22231 Ricci E, Parazzini F, Mirone V, Imbimbo C, Palmieri A, Bortolotti A, Cintio E di, Landoni M, Lavezzari M. Current drug use as risk factor for erectile dysfunction results from an Italian epidemiological study. Int J Impot Res. 2003 Jun 15(3) 221-4. English 2.4 Drugs Which Compromise Erectile Function 579 Impairment of sexual functions is common in patients Incidence of erectile dysfunction drug use as risk factor for erectile dysfunction results from Erectile function Sexual function, impairment Erectile function Sexual function, impairment of overall functions Quantification Erectile function Quantification Erectile function Sexual function, impairment Psychosis Erectile function Erectile function, impairment Improved with sildenafil No 1605 Atmaca M, Kuloglu M, Tezcan E. Sildenafil use in patients with olanzapine-induced erectile dysfunction. Int J Impot Res. 2002 Dec 14(6) 547-9. English Psychosis Erectile function Erectile function,...

Side and Adverse Effects of Some Phytocompounds

Many adverse drug-herb interactions constitute a great danger for patients and might adversely affect the monitoring of certain drug therapies, such as an increase in bleeding time (garlic and ginseng both interact with warfarin) 95, 96 . Other examples include the action against standard immunosuppressants, life-threatening allergic reactions such as contact dermatitis and anaphylaxis (Echina-cea), interference with the monitoring of digoxin (ginseng, hawthorn, licorice, etc.), and hepatotoxicity (kava-kava with alprazolam) 5, 44, 95, 97-109 .

Neuron For A Neuron

Until 1973, homosexuality was listed as a psychiatric disorder in the Diagnostic and Statistical Manual of Mental Disorders (DSM). Up until June 2003, when the United States Supreme Court declared them unconstitutional,140 thirteen states had laws making it a criminal offense to engage in consensual homosexual sex. In some of these states, people who admitted that they were homosexual, or who were accused of being gay or lesbian, were subject to involuntary confinement under mental health laws, and subjected to reparative therapy designed to forcibly convert them into heterosexuals.141 Treatment, in addition to counseling, included penile plesthysmograph shocks (electronic shock triggered by penile erection), drugging, and hypnosis. Some state laws even permitted the forcible sterilization of homosexuals.142

Other Nervous System Drugs

Sexual side effects have been well proven by multiple studies. In particular, the erectile function is compromised. Among the patients who complain of erectile dysfunction, there are more smokers and heavy smokers (40 vs 27.7 , and 39.2 vs 4 , respectively) than in the general population. The prevalence of erectile dysfunction in 1162 never smokers was 2.2 , in 1292 former smokers 2.0 and in 2008 current smokers 3.7 (Mannino et al. 1994). The odds ratio (OR) for suffering from erectile dysfunction is significantly higher in smokers and in ex-smokers than in never smokers (OR 1.24-2.2, in all studies significantly enhanced). The association with pack-years suggested a dose-response pattern. Only one study published decribes no correlation of current cigarette smoking with erectile dysfunction, but the duration was positively correlated with erectile dysfunction (p

Overall level of evidence of adverse effects B

Erectile dysfunction IIEF Erectile function, impairment 1272 Bacon CG, Mittleman MA, Kawachi I, Giovannucci E, Glasser DB, Rimm EB. A prospective study of risk factors for erectile dysfunction. J Urol. 2006 Jul 176(1 ) 217-21. English Erectile dysfunction in diabetes mellitus Erectile function Erectile function, impairment 21304 Bortolotti A, Fedele D, Chatenoud L, Colli E, Coscelli C, Landoni M, Lavezzari M, Santeusanio F, Parazzini F. Cigarette smoking a risk factor for erectile dysfunction in diabetics. Eur Urol. 2001 0ct 40(4) 392-6 discussion 397. English Erectile dysfunction Erectile function, self-reported Erectile function, impairment 1273 Millett C, Wen LM, Rissel C, Smith A, Richters J, Grulich A, de Visser R. Smoking and erectile dysfunction findings from a representative sample of Australian men. Tob Control. 2006 Apr 15(2) 136-9. English Erectile dysfunction Erectile function Erectile function, impairment Prevalence of erectile dysfunction in 1162 never smokers 2.2 , in...

Evaluating Alternative Remedies

It's important to know that a remedy can be therapeutic at one dose but cause problems if the dose is too high. Just because it's natural doesn't mean that you can't take too much. For example, in small doses, vitamin A is essential for proper metabolic function, especially aiding vision, but large doses can cause yellowing of the skin. Large doses of vitamin B6 can cause clumsy hands and feet and numbness around the mouth. The high doses of vitamin C used by some people in the mistaken belief that it wards off colds can interfere with the absorption of vitamin B12, increase estrogen levels, and increase the possibility of kidney stones. Calcium supplements can help osteoporosis, but too much may cause kidney stones and induce a zinc deficiency. Zinc is touted to help sexual functioning, but an excess can cause ulcers, anemia, and inflammation of the pancreas.

Sexual and reproductive function

Ironically, some of the drugs that increase a teen's risk of engaging in sexual activity can also impair his or her sexual and reproductive functioning. A large number of studies have shown a link between alcohol use and sexual dysfunction. According to Medications That May Contribute to Sexual Disorders, a 1997 article in the Journal of Family Practice, chronic alcohol abuse can suppress normal hormonal functions such as sexual arousal. It can also reduce the size of the testes. The 2003 Health Professionals Follow-up Study reported that impotence was more common among men who drank alcohol. Drugs other than alcohol can also have a negative effect on sexual function. The 1997 article reported that cocaine use may hinder the ability to attain an erection or achieve orgasm. Like cocaine, chronic use of amphetamines also affects orgasm and erection. Barbiturates can impact sexual function as well by reducing desire and making it difficult to achieve erection or orgasm. A 1996 article,...

Epidemiological Data

From a population-based telephone survey, 5 of the respondents reported giving their children herbal medicines in the past year 61 . In a national online survey, 41 of 520 adolescents reported to have used herbal remedies in the previous 6 months, mainly ginseng, ginger, Ginkgo biloba, valerian and St. John's wort 62 . The results of another study conducted in four primary paediatric care practices in Washington showed that 8 of children had been treated with herbal therapies in the prior year 58 . Other authors 63 verified herbal use among 2562 families in Kansas and Wisconsin through questionnaires child herbal use was indicated in 35.8 of the surveys. The herbs most commonly taken by children were chamomile, Aloe vera, peppermint, garlic and lavender.

Pregnancy Category C

Most persons find the drug unpleasant if the medically recommended dosage is exceeded, with unwanted effects such as easy excitability, memory trouble, nausea, itching, interference with male sexual function, slurred speech, trouble with thinking, and difficulty with moving arms and legs. Some persons become tired and woozy even on normal doses. Nonetheless, one study of cough medicines found that volunteers preferred dextro-methorphan to other remedies that were effective, leading the researchers to speculate that the drug was providing pleasure unrelated to effectiveness in relieving cough. Indeed, some users feel more sociable and report euphoria and hallucinations. Cases of mania are known, likened to the kind of stereotypical behavior popularly associated with PCP. In one instance, the compound allowed a lawyer to work industriously for weeks with little sleep, followed by mental collapse requiring hospitalization. This individual had engaged in manic episodes and drug...

Imino2 phnyl5 oxazolidinone4

Imperial Group Leading British manufacturer of tobacco products, including Player and Embassy cigarettes, Wilson's snuff, and several brands of cigars. Its other products included beer, prepared foods, and packaging. Corporate headquarters are in London. Impfen German colloquial term for adding opium to hashish. Import Colloquial term for crack. Impotence Inhibited sexual excitement in a man during sexual activity that, despite an unaffected desire for sex, results in inability to attain or maintain a penile erection. Impotence can result from psychological factors (performance anxiety or fear of abandonment or unwanted pregnancy), sociocultural factors (negative sexual attitudes or religious beliefs) or, less frequently, physical causes such as hormonal abnormalities, drug abuse and alcoholism. Treatment of impotence depends on the underlying cause. Many drugs are used as aphrodisiaca. Central stimulants lika amfeta-mine and cocaine initially acts as sexual stimulants but can have...

Effects And Risks Of Smoking

Besides the danger of nicotine addiction, cigarette use poses a wide range of threats to the user's health. The main health dangers include increased risk of heart attack, respiratory diseases such as emphysema and lung cancer, cancer of the mouth and throat, and pancreatic cancer. About one in six men who continue to smoke tobacco will develop lung cancer compared to one in 75 nonsmokers. Male smokers are also 85 percent more likely to suffer from impotence than nonsmokers are. Other diseases linked to smoking include various forms of cancer, stroke, cardiovascular disease, bronchitis, cataracts,

General adverse reactions

The adverse effects of disopyramide are mostly mediated by its effects on the cardiovascular system and by its anticholinergic effects. Disopyramide has a strong negative inotropic effect on the myocardium and can cause heart failure and hypotension. It prolongs the QT interval and can cause serious ventricular tachydysrhythmias. Anticholinergic effects can cause dry mouth, blurred vision, urinary retention, glaucoma, and erectile impotence. Hypoglycemia can also occur. Disopyramide can cause uterine contractions and should not be used during pregnancy. Angioedema has been reported rarely. Tumor-inducing effects have not been reported.

Spanisches Rohr Arundo donax

Speed o Colloquial term for root of ginseng. Speed of lovers Colloquial term for MDA. Speed quarters A drinking game frequently started by alcoholic members of a social group to appear as a normal drinker - this is an even faster version of quarters. Speed run Colloquial term for up to 1,000 mg. of metamfetamines in a single injection. Speed trip Colloquial term for high feelings from use of amfetamines. Speed, natural Colloquial term for root of ginseng.

OTC Classification in Japan

Lifestyle drugs received much publicity (5456) since the launch of the little blue pill, Viagra. The publicity is fueled partly by the hype cf the media and partly by the debates about who is going to pay and what are their therapeutic benefits to the consumers (57-61). The scientific field is equally interested in this class of drugs, as reflected by a dedicated Scrip report (62), an article in the British Medical Journal (63), and a special series of articles in the International Journal ofClinical Pharmacology (64-68). Increase muscle mass or height Quality of life improvement Incontinence Impotence Influenza Lifestyle Postpone menstruation Smoking cessation Contraception Weight control Dyspepsia Sun protection Psychological Anti-depression Obsessive-compulsive disorder Social anxiety disorder The other controversy is what benefits do lifestyle drugs offer the consumers because they are primarily treating non-life-threatening diseases. Diseases such as incontinence and impotency...

Amfetamines Introduction One of a

A typical sign of amfetamine intoxication is wide pupils, fast talk and aggression. AMFETAMINES - Mental effects Moderate use of amfetamine can give euphoria, self-confidence, weight loss and sexual stimulation for many hours. These effects explains the popularities of the amfetamine-pills in the 1930s through the 1960s. After repeated long-term use a schizophrenialike psychosis can develop. The first amfeta-mine-psychosis occurred in 1938. Administration of amfetamine to volunteers with no history of psychosis have showed that a majority of the persons develop paranoid psychosis after already after one to five days of administration. The symptoms wear off after the drug is discontinued usually within a week. Of ethical reasons experiments with healthy persons has been limited, but the amfetamine psychosis represent a reasonably accurate model of schizophrenia , including symptoms of paranoia, persecution, hyperactivity, excitation, hallucinations (visual and auditory) as well as...

Problems In The Evaluation Of Clinical Results

Sexual experiences and behavior can be deeply influenced by the LSD pro-cess. The intensity, depth and completeness of the sexual orgasm and the ease with which it occurs seems to be closely related to the process of letting go of psycho-1 logical defenses. Many problems in this area can be traced back to unconscious confusion between the pattern of genital orgasm and that of the total physical release that characterizes the orgasm of birth. As LSD subjects learn to let go in the death-rebirth process, their orgasmic ability increases considerably this improvement of sexual experiences can be observed in both males and females. In those individuals who did not have any major psychopathological symptoms prior to the LSD session, the same effect can usually be observed after one or several high-dose psychedelic experiences. Sexual neuroses, such as frigidity, vaginal spasms (vaginism), genital pain during intercourse, impotence and premature ejaculation frequently respond well to LSD...

Classical Mandrake Prescriptions

Recreational Drugs America

The origin of Chinese pharmacology is ascribed to the mythical emperor Shen Nung. Tradition has it that he tested a hundred drugs on himself and, because he could make his system transparent at willl (what a nice metaphor for seeing into oneself _ with drugs), he was able to observe their action and take an antidote if necessary. He was thus able to classify them superior drugs were Lionpoisonous and rejuvenating medium were somewhat toxic, depending on dose and inferior were poisonous, but useful in certain illliesses. The fust Chinese pharmacopoeia (pen ts'ao) followed this scheme and was attributed to Shen Nung, though it was actually, compiled by scholars of die Han dynasty (206 b.c.-a.D. 220). It listed 365 therapeutic herbs-one for every day of the year-including hemp, ephedra, rhubarb, licorice, sesame, ginger, cassia, cinnamon and the marvelous aphrodisiac and cure-alL_ ginseng. Like mandrake in ihe West, the more ginseng root resembled the human body, the more effective it...

An Ancient Mushroom Ceremony

Hippies Passing Joint

Magazines like High Times carry ads for lettuce opium, magic mushroom spores, aphrodisiac yohimbine smoking mix, cosmic think-drink (Gotu kola). Legal grass contains Korean ginseng leaves, damiana, high-grade lobelia herb, yohimbine bark and hops. A combination of yohimbine bark and kavakava root is described as feeling like mellow acid. Kola nut and chia seeds are combined in organic speed. Sales of pamphlets on legal highs and herbal aphrodisiacs and numerous magic-mushroom field guides testify to the mania for organic highs. Far more species of psychoactive plants exist than have been declared illegal, and new ones await discovery. The Ch urch of the Tree of Life and other Neo-American religious groups have followed the example of the peyote using Native American Church in declaring as their sacrament plant hallucinogens that are presently legal

History of Medical Marijuana

The mystical Chinese emperor Shen Neng introduced these pharmaceutical uses of cannabis. He also discovered many other medicines. These included ephedra, a natural stimulant that helped asthma and led to the invention of amphetamine camellia sinensis, the first caffeinated tea and ginseng, the popular herbal panacea (Aldrich, 1997). Legends often develop around people who make new discoveries, and Shen Neng is no exception. He purportedly could see into his own stomach and observe the impact of herbs on his body, making him a phenomenal authority on their pharmaceutical effects (Wallnofer & Von Rottauscher, 1965). Emperor Shen Neng prescribed cannabis tea for gout, malaria, beriberi, rheumatism, and, curiously, poor memory (Abel, 1980). Although other treatments have developed for most of these maladies, marijuana's impact on rheumatism remains part of modern research (Turner & ElSohly, 1981). Medical marijuana spread farther while new uses for it developed back in...

Medical And Behavioral Toxicity Overview

Cortisol is a hormone (chemical messenger) responsible for multiple effects on the body, including changes in the immune response, glucose regulation, fat breakdown, blood pressure, and mood. Alcohol-induced cortisol excess can mimic Cushing's disease (a condition associated with excess cortisol production, often caused by a tumor on the adrenals) and is known as pseudo-Cushing's disease. Alcohol affects the hypothalamus (an area of the brain), where it modifies chemical-releasing factors, which in turn control release of hormones from the pituitary (a gland in the brain linked to the hypothalamus by a special blood supply), which in turn affect endocrine organs throughout the body. Acutely, alcohol also inhibits the release of antidiuretic hormone (ADH) from the posterior pituitary, which results in increased urine production. The best documented chronic endocrine effect of alcohol is male hypogonadism, a condition resulting from low sex-hormone function. Signs of the condition are...

Adulteration and Contamination

Adulteration in Asian medicines mostly results from the misidentification of plants. This has resulted in a number of serious events, primarily due to poisoning with digitalis, belladonna, skullcap, etc. 8 . In 1998, the California Department of Health reported that 32 of Asian patent medicines sold in the US contained undeclared pharmaceuticals or heavy metals 60, 61 . The FDA and other investigators have also reported the presence of prescription drugs, including glyburide, sildenafil, colchicines, adrenal steroids, alprazolam, etc. in products claiming to contain only natural ingredients 62 .

Ape Drunk Colloquial term for being slightly

Central stimulants as amfetamines and cocaine has an aphrodisiac effect and is often connected with sexual activities. When central stimulants are abused for a longer time, the pleasure of the drug kick becomes more desirable than sexual stimulation and a paradoxal effect disinterest in sexual activity can appear. In rehabilitation of cocaine and amfetamine abusers the sexual aspects are important. Sexual activities is often strongly connected with drug-taking often with multiple partners or hours of masturbating with pornography. Drug-free sex can therefore be complicated and initially cause impotence. Despite long-standing literary and popular interest in internal aphrodisiacs, few scientific studies of them have been made. Scientific research is limited to occasional tests of drugs or hormones for the cure of male impotence. Most writings on the subject are little more than unscientific compilations of traditional or folkloric material. Of the various foods to which aphrodisiac...

Prospects for Herbal Medicine

Mineral Ocorticosteroid Functioning

The US Food and Drug Administration (FDA) has published guidelines for standardized multicomponent plant extracts referred as botanical drugs, thus making it possible to market these products under the New Drug Administration (NDA) approved process 16 . Common botanical dietary supplements sold in the USA are Echinacea purpurea, Panax ginseng, Serono repens, Ginkgo biloba, Hypericum perforatum (St. Johns wort), Valeriana officinalis, Allium sativum, Hydrastis canadensis, Matricaria chamomilla, Silybum marianum, Trigonella foenum-graecum, Tanacetum parthenium, Ephedra sinica, and Cimicifuga racemosa 3 . At present the basis for marketing of these products in the US is the Dietary Supplements Health and Education Act (DSHEA) of 1994, which allows manufacturers to market products as dietary supplements without the rigorous testing required for other drug products

Endocannabinoids and regulation of fertility

Blastocyst

The adverse effects of cannabinoids, and in particular of A9-tetrahydro-cannabinol (A9-THC), on reproductive functions have been known for a long time 1,2 , and include retarded embryo development, fetal loss and pregnancy failure (recently reviewed in 3, 4 ). A9-THC has been reported to account for the majority of the reproductive hazards of marijuana use, in particular in males it leads to impotency by suppressing spermatogenesis, by reducing the weight of reproductive organs and by decreasing the plasma concentration of circulating hormones like testosterone. In females, A9-THC inhibits ovulation by prolonging the estrous cycle and decreasing the proestrous surge of luteiniz-ing hormone. In addition, exposure to natural cannabis extracts during pregnancy has been correlated with embryotoxicity and specific teratological malformations in rats, hamsters and rabbits. Also the major endocannabinoid anan-damide (N-arachidonoylethanolamine, AEA) has been shown to impair pregnancy and...

Late Toxicity After Radiochemotherapy

In most of the recent series with organ preservation, about 70 -80 of long-term survivors maintained a normal functioning bladder. Preservation of a functioning bladder can be achieved in three quarters of patients with muscle-invading tumors. The current data show a good to excellent bladder function in the vast majority of patients. There are few data on quality of life in long-term survivors after therapy for bladder cancer and patients seem to adapt well even in case of radical cystectomy with urinary diversion however, the impact of cancer therapy of sexual function is poorly examined, especially in females, but is likely very high (Zietman and Skinner 2005).

The Long Term Health Effects of Methamphetamine

Health Effects Methamphetamine

The temporary physical and psychological effects from meth can turn into long-term, permanent effects that last a lifetime. For instance, meth dramatically affects a person's decision-making abilities. The temporary effect of increased libido leads meth users to engage in risky, unprotected sex. A recent study of 19,000 men in Los Angles showed that new HIV infections were three times higher among methamphetamine users than among nonusers.28 Also, HIV and other infectious diseases like hepatitis B and C are spread among injection drug users mainly by sharing syringes and needles. Multiple injections also scar the skin and the veins. Because of the eventual reversal of meth's effects, long-term meth-amphetamine use is associated with decreased sexual functioning and libido, at least in men.9, 11

Chemistry and Structure Activity Relationships

Sildenafil (6) is a pyrazolopyrimidinonederiv-ative. The pyazolopyrimidinone ring is essential for PDE5 inhibitory activity. It seems that this ring structure mimics the guanosine base of cGMP (149). Another ring system that has been shown to produce potent and selective PDE5 inhibitory activity is imidazoquinazoli- (6) Sildenafil Citrate (6) Sildenafil Citrate none (150). In the sildenafil series, the n-pro-pyl substitution on position 3 of the pyazolopy-rimidinone ring gives a more potent compound compared with a 3-methyl analog. Intramolecular hydrogen bonding of sildenafil and its analogs is important for biological activity by maintaining co-planarity between the phenyl and purine ring (151). The 2'-alkoxy moiety on the phenyl group serves this purpose by providing the oxygen lone pair for hydrogen bonding with the pyrimidinone NH (149). The alkoxy moiety also provides the requirement for a small lipophilic substituent, which is important for activity. Replacement of the alkoxy...

Hair Growth Disorders

The clinical dose of finasteride is well tolerated. The main side effects reported in phase III clinical studies were sexual function disorders including decreased libido, ejaculation disorders, and erectile dysfunction. All these sexual disorders were mild-to-moderate and were reversed on discontinuation of the drug, and in some patients, they resolved even with continued therapy (86). A 5-mgdose in hirsute women was well tolerated with no significant side effects, although the risk of developing abnormalities in the external genitalia of male fetus, if the drug is taken or a crushed tablet is handled by a pregnant woman, causes a great

Ecstasy As A Date Rape Drug

Ecstasy is not as commonly used as a date rape drug as GHB or Rohypnol, primarily because it does not incapacitate the victim or make him or her unable to ward off sexual advances. In addition, Ecstasy is relatively insolu-able in many liquids. Also, Ecstasy actually tends to make male users impotent and unable to achieve an erection. This impotence is increasingly common in men who repeatedly use Ecstasy. This has spurred the popularity of a new drug combination, Viagra (a drug that helps men achieve erections) and Ecstasy, which male users take so they can remain sexually functional while high on Ecstasy. This combination is quite risky, however, with numerous side effects such as heart problems, high blood pressure, and even death, especially when taken with another drug called amyl nitrate ( poppers ).

Histamine H2 receptor antagonists

Changes in healthcare utilization resulting from a formulary switch from nizatidine to cimetidine have been studied in 704 patients (4). There was no evidence of increased healthcare utilization during the 6 months after the formulary switch, which led to considerable pharmaceutical savings. During this period only four (0.004 ) adverse drug reactions associated with cimetidine were reported urticaria, nausea and vomiting, leg cramps, and impotence.

Previous Chronic Cannabis Use Studies

In 1980, Cannabis in Costa Rica A Study of Chronic Marihuana Use was published (Carter 1980). Forty-one subjects smoking for 10 years or more were recruited. Although 10 or more cigarettes per day were smoked, the weight of material was only 2 g with an estimated THC range of 24-70 mg per day. Thirteen samples were assayed with a range of 1.27-3.72 , and average of 2.2 THC. Claims of benefit for cough, asthma, headache, hangovers, anorexia, impotence, depression and malaise were mentioned, but once more, the focus was on social use.

Establish the Presence of a Specific Psychiatric Syndrome

For example, a man I once saw complained of unhappiness that had troubled him for many years. He very much wanted to try Prozac. Although he found that his mood slightly improved, he noticed marked sexual dysfunction. He decided that he would rather stay off antidepressants and avoid the sexual dysfunction, in part because his depression was mild and did not impair his ability to lead his life. He began to exercise regularly, decreased his work week to four and a half days a week from six, and spent more time with his wife in leisure activities. These changes helped his depression more directly without impairing his sexual functioning, and he decided to stay off antidepressants.

Other Peripheral Vasodilators

Sildenafil (SED-14, 636 SEDA-23, 215 SEDA-24, 231 SEDA-25, 238) The adverse effects of a single dose of silde-nafil 50 mg have been evaluated in a placebo-controlled study in 40 young healthy volunteers (5c). The most commonly reported adverse effects with sildenafil and placebo respectively were flushing (75 and 0 ), headache (50 and 5 ), and dyspepsia (15 and 5 ). This adverse effects profile was similar to that observed in clinical trials. Heart rate changed significantly, but blood pressure did not. Nervous system Clinical trials of sildenafil have not shown increased risks of stroke or myocardial infarction. However, postmarketing drug surveillance programs have mentioned strokes associated with sildenafil, and the first case reports have now been published. A 50-year-old man took sildenafil 50 mg, and 2 hours later developed a right-sided hemiparesis and altered hemibody sensation, a right facial paresis, and slurred speech (6A). The symptoms gradually disappeared 4 hours later,...

Adenanthera pavonina L

Uses In Burma, a paste made from the seeds of Adenanthera pavonina L. is applied externally. In Malaysia, the leaves are used to invigorate health. In India, a decoction of the leaves is used externally to treat chronic rheumatism, gout and impotence, and to treat bleeding. The seeds are used in necklaces.

A10Drugs Used in Diabetes

It has been well proven that there is a higher prevalence of erectile dysfunction in diabetic men than in non-diabetic men. The figures of the odds ratio vary between 1.04 and 6.97. In most studies the confidence interval does not include 1.0, i.e. there is a significant difference. Only one study has found no increase of the risk with medication of antidiabetics. The incidence of erectile dysfunction increases with the duration of the disease a 10 higher risk was calculated with each year of duration of diabetes, and it was even higher in combination with depression and cardiac disease. In a duration of diabetes 5 years 56 of men had erectile dysfunction, and 72 of men with 20 years of diabetes. On the other hand, the prevalence of diabetes mellitus in men with erectile dysfunction was significantly higher than in a control group of non-impotent men. Although there are a number of well-conducted case-control studies, it remains unanswered as to whether the disease itself or the...

Regulation of other receptors

It has an inhibitory effect on the cardiovascular system. Ergometrine also has a high affinity to uterine a2 receptors, and it therefore influences uterine muscle activity. Ergometrine is used in the treatment of postpartum or postbortal haemorrhaging. Yohimbine blocks presynaptic a2 adrenoreceptors and increases the release of noradrenaline at sympathetic nerve endings. It may be used to increase heart rate and blood pressure and even in the treatment of severe cases of male impotency.

Social Anxiety Disorder

Treatment is started at standard dose and increased as necessary (e.g. paroxetine 20-50 mg). Duration of treatment is usually for at least 12 months, and there is benefit from combination with CBT (Blomhoff et al. 2001). The other class of antidepressant to be considered is the MAOIs, as phenelzine and moclobemide have controlled trial data to support their use (Versiani et al. 1992). TCAs have no proven efficacy and evidence for venlafaxine and mirtazapine is awaited. Among the benzodiazepines only clonazepam has been shown to be effective as monotherapy, possibly due to its effects on 5HT1A receptors (Davidson et al. 1993b). Benzodiazepines may also be used to augment SSRI treatment. Other drugs to consider are the anticonvulsant gabapentin and the antipsychotic olanzapine. -Blockers are not effective in generalized social anxiety disorder but have a role in symptomatic control in specific performance anxiety.

Im Built Like a Bean Pole

Not long after we began training, one of my lifting buddies showed up with a pill that he says will help us get bigger and stronger faster. The pill is a steroid, and he told us it is harmless and said if we really want to get really big we can stack steroids. I wasn't totally sure about this, so I went to talk with Coach Smith. She told me that stacking is when two or more anabolic steroids are taken together. people who stack mix oral and injection steroids and sometimes add drugs like stimulants or painkillers. She said the idea behind stacking is an unproven belief that the different drugs interact to produce a greater effect on muscle size. She also said we needed to be careful because steroid use had some really nasty side effects. It can cause acne, reduce a guy's sperm count, shrink the testicles, lead to impotence, result in difficulty or pain in urinating, baldness, and even irreversible breast enlargement. She said that the long-term effects can include cancer and possibly...

Allan Mazur

Adverse effects of drugs on sexual functions are often neglected in practical medicine, because they are usually mild or moderate and rarely prompt hospital admissions, denominated as severe ADEs. In addition, standard textbooks of pharmacology and those which discuss drug side effects consider these topics only marginally, and well-known sexual side effects are not mentioned. There are, of course, a number of review articles on the possible adverse effects of drugs on sexual dysfunction, in particular on erectile dysfunction. But delineations of the exact figures of the incidence of sexual adverse effects in a concrete drug are often lacking in these papers. Reviews also frequently do not describe the database of the reported adverse effects, thus leaving the quality of evidence uncertain. This book summarizes quotations from the literature which describe particular effects of drugs on male sexual functions. A special concern of the composition is the information on the quality...

How safe is cannabis

Enthusiasm for cannabis in the 1960s and early 1970s was rapidly followed by a wave of reaction in the Western world. Extravagant warnings were issued, suggesting that cannabis was a highly dangerous drug that could cause chromosomal damage, impotence, sterility, respiratory damage, depressed immune system responses, personality changes, psychosis, and permanent brain damage (1R, 2S). Most of these claims were later proved to be spurious, and balanced reviews (3R-5R) have shown how effectively many of them have been demolished.

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Option

While I fully support marijuana's use for medicinal purposes, why don't we regulate it like we do Lipitor or Viagra You can't buy those two without getting it through a legitimate pharmacy. If this drug is so important and so helpful, why is it not regulated like every other drug They pass a law, then they have no regulations as to how to enforce the darn thing and, as a result, we have hundreds of these locations selling drugs to every Tom, Dick and Harry.16

And Drugs

The descriptions of the effects of ADEs on male sexual function are generally scarce and restricted to few topics. Any intervention which influences the sexual hormone system obviously also influences male sexual functions, e.g. antian-drogenic compounds, which depress sexual libido and other sexual functions. In some circumstances, it may be questionable as to whether the effect of a drug on male sexual functions is a desired therapeutic effect, or whether it is an untoward effect. For example, the depression of pituitary hormone secretion by the gonadotropin-releasing hormone (GnRH) analogues in the treatment of prostate carcinoma is important in order to achieve androgen deprivation and prolong the remission of the disease. On the other hand, the depression of gonadotropin secretion in these men by GnRH leads to impotence and infertility, which is definitely an untoward effect. Some sexual ADEs which occur during treatment of other diseases are broadly recognized, e.g. erectile...

Terpenes

All plant steroids hydroxylated at C3 are sterols. Steroids are modified triter-penes and have profound importance as hormones (androgens such as testosterone and estrogens such as progesterone), coenzymes and provitamins in animals. Many progesterones are derived semisynthetically from diosgenin. Saponins are C27 steroids widely distributed in monocot families like Liliaceae, Amaryllidaceae and Dioscoreaceae, and in dicot families, e.g. Scrophulariaceace and Solanaceace. Saponins are composed of two parts the glycone (sugar) and the aglycone or genin (triterpene). Commercially important preparations based on saponins include sarsaparilla root (Sarsaparilla), licorice (Glycerrhiza glabra), ivy leaves (Hedera), primula root (Primula) and ginseng (Panax ginseng). The ammonium and calcium salt of glycyrrhizic acid are referred to as glycyrrhizins. They are 50 to 100 times sweeter than sucrose 80 .

Nitric Oxide

Laboratory studies indicate a role for NO in mediating many of the actions of ginseng and ginsenosides on copulatory performance. In rats treated for 3 months with oral ginseng extract versus no treatment, there was significantly increased intra-cavernosal pressure following stimulation of pelvic nerves innervating the corpus cavernosum 27 . Ginsenoside-containing extracts of P. ginseng produced a dose-related increase in cGMP and endothelium-dependent dilation and relaxation of penile corpus cavernosum in rabbit 28,29 treatment with the NOS inhibitor N-nitro-L-arginine blocked the ability of ginseng to induce this relaxation. Ginseng extract also enhanced acetylcholine-induced and transmural nerve-stimulation-elicited relaxations in rabbit corpus cavernosum tissue and reversed phenylephrine-induced corpus cavernosum smooth muscle vasoconstriction 30 . Both the neurogenic and endothelium-mediated relaxations were enhanced by superoxide dismutase (SOD), a scavenger of the superoxide...

Conclusions

Human studies have suggested that ginseng ingestion may be a safe and effective alternative method for treatment of erectile dysfunction 10 . Animal studies indicate that ginseng ginsenosides mediate the release and or the modification of release of NO from endothelial cells and perivascular nerves, and the consequent vasodilatation of the penile corpus cavernosum may contribute to the copulatory performance-enhancing action of ginseng. Ginsenosides have been shown to interact with steroid receptors and, through nongenomic pathways, activate NO production. How ginseng and its ginsenosides may act centrally to modulate sexual desire and copulatory performance is not known, but it could potentially involve activation of NO pathways, perhaps in brain areas involved in sexual behavior.

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Dealing With Erectile Dysfunction

Dealing With Erectile Dysfunction

Whether you call it erectile dysfunction, ED, impotence, or any number of slang terms, erection problems are something many men have to face during the course of their lifetimes.

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