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Inhibition of sperm fertilization and capacity completely different action when compared with the physiological functions of the endocannabinoid system as shown by experiments using CB1 receptor antagonist or CB1_ mice. Besides the hypothalamus, peripheral sites of action, such as pituitary and adrenal glands, could participate in the endocannabinoid modulation of the HPA functions. In cultured human ACTH-producing tumors, WIN 55,212-2 was found to be ineffective in influencing basal ACTH...

The Emerging Role of the Endocannabinoid System in Endocrine Regulation and Energy Balance

Uberto Pagotto, Giovanni Marsicano, Daniela Cota, Beat Lutz, and Renato Pasquali Endocrinology Unit, Department of Internal Medicine and Gastroenterology, and Center for Applied Biomedical Research (U.P., R.P.), Sant' Orsola-Malpighi Hospital, 40138 Bologna, Italy Department of Physiological Chemistry (G.M., B.L.), Johannes Gutenberg-University Mainz, 55099 Mainz, Germany and University of Cincinnati, Department of Psychiatry, Obesity Research Center, Genome Research Institute (D.C.),...

Summary and Perspectives

A number of studies show that the endocannabinoid system profoundly influences both hormone secretion and metabolic processes. Animal models have represented the ideal tool for advancing the understanding of the mechanisms of these functions. However, the data derived from early studies were not Fig. 3. Actions of CB1 antagonists on the target organs involved in food intake and metabolic control. Schematic drawing illustrating the main sites of action of CB1 antagonists in the control of energy...