CONHCH2COONa

aL-Lactoyl residue;

&a 1,3,5-benzenetricarboxamide or trimesic acid amide; c2-oxo-3-hydroxy-l-piperidinyl;

Table 10.3 Characteristics of Ionic andNonionic Iodine-Containing Contrast Agents

USÀN or INN Name

Diatrizoate (2b) [737-31-5]

Diprotrizoate (2c) [129-57-7]

Iotrizoic acid (2e) [16024-67-2]

Ioxotrizoic acid (2f) [19863-06-0]

Metrizoate (2g) [7225-61-8]

Ioglicic acid (3a) [49755-67-1]

Chemical Name

3-Acetylamido-2,4,6-triiodoben-

zoic acid Sodium salt Meglumine salt

3,5-Bis(acetamino) -2,4,6-triiodo-

benzoic acid Sodium salt Meglumine salt 3,5-Dipropionamido-2,4,6-tri-

iodobenzoic acid Sodium salt

3-(Acetylamino)-5-[(acetylami-no)methyl]-2,4,6-triiodoben-zoic acid Meglumine salt 2,4,6-Triiodo-3-[(l-oxo-3,6,9,12,15-pentaoxa-hexadec-acid

3-(Acetylamino)-5-[(hydroxy-acetyI)amino]-2,4,6-triiodo-benzoic acid 3-(Acetylamino)-5-(acetylmeth-ylamino)-2,4,6-triiodobenzoic acid Sodium salt

3- (Acetylamino)-2,4,6-triiodo-5-[[[2-(methylamino)-2-oxoeth-yllaminol carbonyl]benzoic acid

65.77 50.62

59.87 47.05

57.34 60.63

46.25 49.89

60.44

60.63 65.78

9.56

5.51ft

11.0e

108^

Solubility, g/ 100 mL H20

at 20°C PK HvO25

94.20

Freely soluble

60 89

2.08

1.88

Ref.

272,273

274,275

mmmmmmmmmmmmmmmmmm tji o

Iothalamic acid (3c) [2276-90-6]

Ioxitalamic acid (3d) [28179-44-4]

Iopanoic acid (4a)

[96-83-3] Iophenoxic acid (4b) [96-84-4] Ioprocemic acid

Tyropanoate (4e) [7246-21-1]

Iolidonic acid (4f) [21766-53-0]

Iomorinic acid (4g) [51934-76-0]

Iolixanic acid (4h) [22730-86-5]

(methylamino) -2-oxoethyl] amino]-carbonyl]-2,4,6-tri-iodo-5-[ (methoxyacetyl)ami-no]benzoic acid 3-(Acetamino)-2,4,6-triiodo-5- 613.92 [(methylamino) carbonyl]-benzoic acid Sodium salt 635.9

Meglumine salt 809.13

3- (Acetylamino)-5[ [(2- (hydroxy- 643.94 ethyl)amino] carbonyl]-2,4,6-triiodobenzoic acid 3-Amino-alpha-ethyl-2,4,6-tri- 570.94

iodobenzene-propanoic acid Alpha-Ethyl-3-hydroxy-2,4,6- 571.92

triiodobenzene-propionic acid 3-(Acetylethylamino)-2,4,6-tri- 612.97

iodobenzene-propionicacid 3- [ [ (Dimethylamino) -methylenel 597.96 amino] -2,4,6-triiodobenzene-propanoic acid Sodium salt 619.94

Calcium salt 1233.99

Alpha-Ethy 1-2,4,6-triiodo-3- [ (1-oxobutyl)-amino]benzene-pro-panoic acid Sodium salt

Alpha-Ethyl-2,4,6-triiodo-3- (2-oxo-1 -pyrrohdinyl)ben-zenepropionic acid 2-Methyl-3-[2,4,6-triiodo-3-[l-(4-morphohnyl)-ethyhdene)ami-nolbenzoyl] aminopropionic acid

2-[2-[3-(iV-Ethylacetamido)-2,4,6- 673.02 triiodo-phenoxy] ethoxy ]propi-

onic acid

663.01 639.01

711.08

85 280

349 281

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