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Randomization of patients Study quality Reference Complete, not based on Ca2+ influx No 885 White DR, Clarkson JS, Ratnasooriya WD, Aitken RJ. Complementary effects of propranolol and nonoxynol-9 upon human sperm motility. Contraception. 1995 Oct 52(4) 241 -7. English Because of the widespread use of 5-phosphodiesterase inhibitors in men with erectile dysfunction, it is essential to test these substances for adverse effects on spermatogenesis, even if the majority of patients treated is beyond...

Side effects compromising effectiveness Randomization of patients Dose arms 13 Study quality Reference

Total testosterone (T), free T (f T), oestradiol (E) levels 20 Significant decrease in E levels, increase in the T E ratio, no changes in T and f T serum levels Not mentioned Tadalafil placebo 11226 Greco EA, Pili M, Bruzziches R, Corona G, Spera G, Aversa A. Testosterone estradiol ratio changes associated with long-term tadalafil administration a pilot study. J Sex Med. 2006 Jul 3(4) 716-22. English 2 Drugs Which Compromise Male Sexual Health Erectile dysfunction Cardiovascular diseases...

Language

Erectile dysfunction, vascular Erectile function In all patients to various degree Not mentioned Phenoxybenzamine papaverine+phentolamine placebo 21549 Szasz G, Stevenson RW, Lee L, Sanders HD. Induction of penile erection by intracavernosal injection a double-blind comparison of phenoxybenzamine versus papaverine-phentolamine versus saline. Arch Sex Behav. 1987 Oct 16(5) 371-8. English Forskolin (not listed), alprostadil, papaverine, phentolamine Erectile dysfunction Erectile function No. of...

Overall level of evidence of adverse effects D

Side effects compromising effectiveness Randomization of patients Dose arms 1-3 Cancer, prostate, treatment with bicalutamide Breast swelling Gynaecomastia and breast pain, development 10 of men treated with tamoxifen+bicalutamide, 73 of Tamoxifen 20 mg day+bicalutamide 150 mg day astronazol 1 mg day+bicalutamide 150 mg day placebo+bicalutamide 150 mg day 1 + 931 Boccardo F, Rubagotti A, Battaglia M, Tonno P di, Selvaggi FP, Conti G, Comeri G, Bertaccini A, Martorana G, Galassi P, Zattoni F,...

Overall level of evidence of adverse effects C

Disease treated Quantification of adverse effects No. of patients treated Age group Treatment period Dose Randomization of patients Dose arms 1-3 Study quality Reference LH levels increase, T levels unchanged, prolactin levels Cocaine nicotine 21323 Mendelson JH, Sholar MB, Mutschler NH, Jaszyna-Gasior M, Goletiani NV, Siegel AJ, Mello NK. Effects of intravenous cocaine and cigarette smoking on luteinizing hormone, testosterone, and prolactin in men. J Pharmacol Exp Ther. 2003 Oct 307(1)...

Capacitation and Acrosome Reaction

A number of voltage-gated Ca2+ channels have been described, but the contribution of each of them to sperm physiology is not clear. The knowledge would be a prerequisite for a pharmacological alteration of sperm function via specific ion channels. Ca2+ channel blockers, which are used, for example, in hypertension, indeed influence sperm function, but they do not induce infertility. For other ion channels, some insights into their role in sperm function are present (e.g. K+ channels are...

Overall level of evidence of adverse effects B

Disease treated Quantification of adverse effects No. of patients treated Age group Treatment period Dose Randomization of patients Study quality Reference Prevalence of erectile dysfunction as compared with non- 2210 Bacon CG, Mittleman MA, Kawachi I, Giovannucci E, Glasser DB, Rimm EB. Sexual function in men older than 50 years of age results from the health professionals follow-up study. Ann Intern Med. 2003 139(3) 161 -8. English Disease treated Quantification of adverse effects No. of...

None 4 review

775 Adler ID, Cochrane J, Osterman-Golkar S, Skopek TR, Sorsa M, Vogel E. 1,3-butadiene working group report. Mutat Res. 1995 Aug 330(1 -2) 101-14. English 2 Drugs Which Compromise Male Sexual Health Butadiene, organic solvents (not listed) Alteration of number and quality of progeny 2044 Hales BF, Robaire B. Paternal exposure to drugs and environmental chemicals effects on progeny outcome. J In wild rodents in humans not proven 231 Moseman RF. Chemical disposition of boron in animals and...

Consequences

Side effects compromising effectiveness Randomization of patients Dose arms 1-3 Study quality Reference Testosterone levels decreased, libido and potency were not altered 5 mg day CPA 10 mg day CPA 2618 Roy S, Chatterjee S. Studies with cyproterone acetate for male contraception. J Steroid Biochem. 1979 Jul 11 (1 B) 675-80. English Randomization of patients Study quality Reference Morphological anomalies of midpiece and tail after 2 weeks, and of heads after 4 weeks No 654 Fredricsson B. On the...

Antihypertensives

Erectile dysfunction is claimed to be a frequent side effect of antihypertensive treatment. Also patients themselves are convinced that their impotence is caused by antihypertensive drugs they take, and many physicians support this opinion however, as early as 1978 Bauer et al. stated that the extent of sexual function impairment is age-related as compared with that observed in men not taking antihypertensives. Ten year later, Bansal (1988) quoted that the reported studies did not clearly...