Each compound in a library produced by solid-phase methods will generally have a structural feature, usually a functional group, associated with its covalent linkage to a resin bead. This feature becomes an obligatory part of every compound in the library - they will all be amines, phenols, acids, etc. depending on the type of linker used. Such features are not always desirable, and considerable effort is being invested in the development of 'traceless' linkers - often silicon based (see Chapter 4). Another approach utilizes intramolecular displacement cleavage strategies in which a (desirable) new ring is formed at the cleavage stage.
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