As stated in Section 26.3.2, plasma protein binding is one of the key factors determining the distribution of a compound within the body. This parameter can be measured using plasma itself or by using single plasma proteins such as albumin or acidic aj-glycoprotein to estimate plasma binding. The latter has the advantage that the measurements can be carried out in a relatively straightforward way and with a high throughput . If a dataset of sufficient size and enough chemical space is available, this parameter can also be predicted from the structure, using the same methods as those described in Section 26.4.1.
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