Plasma Protein Binding

As stated in Section 26.3.2, plasma protein binding is one of the key factors determining the distribution of a compound within the body. This parameter can be measured using plasma itself or by using single plasma proteins such as albumin or acidic aj-glycoprotein to estimate plasma binding. The latter has the advantage that the measurements can be carried out in a relatively straightforward way and with a high throughput [92]. If a dataset of sufficient size and enough chemical space is available, this parameter can also be predicted from the structure, using the same methods as those described in Section 26.4.1.

Was this article helpful?

0 0

Post a comment