The application of combinatorial methodologies to the synthesis of metal-binding agents may be considered as one of the starting points in the development of organic and organometallic catalysts by combinatorial methods. Since combinatorial methods have their origin in the field of peptide library synthesis, it is not surprising that libraries of peptide-based compounds have been studied to identify new sequences with high affinity for transition metals. A traditional approach to new metal-binding agents is based on core receptors that have already established binding properties and the modification of their substitution patterns to induce changes in binding strength and selectivity. In their efforts to identify novel ligand structures, researchers may as well take advantage of constructing building blocks that incorporate metal ion coordinating functional groups and link them in a manner such that selective metal binding may result.
Was this article helpful?