Mimics for acyl transferases require a concerted interplay between tethered functional groups where the catalyst should possess a suitable base that is covalently tethered in close proximity and the correct orientation relative to a nucleophilic center. Taylor and Morken reported the preparation of a library of 3150 distinct nucleophilic acylation catalysts on approximately 7000 encoded polymer beads prepared by "split-and-pool" methods . Their "trimeric" catalysts consisted of a primary amine, a protected amino acid including the capping agent N-4-pyridylproline, and functionalized carboxylic acids (Scheme 32.7). Temperature
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