Introduction to Combinatorial Chemistry

David L. Coffen and Joachim E. A. Luithle

2.1 Combinatorial Chemistry in Drug Discovery - a Perspective 10

2.2 Key Issues 11

2.3 Combinatorial Synthesis 15

2.3.1 Solid-phase Combinatorial Synthesis 16

2.3.1.1 Reagents and Conditions 16

2.3.1.2 Automation 17

2.3.1.3 Split and Combine 17

2.3.1.5 The Products from Solid-phase Chemistry 19

2.3.2 Solution-phase Combinatorial Synthesis 19

2.3.2.1 Reagents and Conditions 19

2.3.2.2 Scavenger Resins, Polymer-supported Reagents and Fluorous Tags 20

2.3.2.3 Equipment and Costs 22

2.4 Conclusion 22 References 22 Valuable Internet Links 23

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