Instrumentation for Combinatorial Chemistry 190

Marcus Bauser and Hubertus Stakemeier

6.1 Automation in Combinatorial Synthesis 190

6.1.1 General Remarks 190

6.1.2 Fully Automated Systems for Solid- and Solution-phase Synthesis 190

6.1.2.1 Robot-arm-based Systems 190

6.1.2.2 Fully Automated Workstation Systems 201

6.1.2.3 Modular Systems 207

6.2 Purification of Combinatorial Libraries 209

6.2.1 Automated Liquid-Liquid Extraction 210

6.2.2 Solid-phase Extraction 211

6.2.3 Normal Phase Chromatography 212 6.2.3.1 CombiFlashâ„¢ from Isco 212

6.2.3.2 Quad3TM from Biotage 212

6.2.3.3 FlashMasterâ„¢ from Jones Chromatography 213

6.2.4 Reversed Phase Chromatography 213

6.2.4.1 Biotage 214

6.2.4.2 Gilson 214

6.2.4.3 Merck 215

6.2.4.4 Varian 215

6.2.4.5 Shimadzu 215

6.2.5 Preparative HPLC-MS 215

6.2.5.1 PE Sciex 215

6.2.5.2 Waters Micromass 216

6.2.5.3 Merck-Hitachi 216

6.2.5.4 Shimadzu 216

6.2.5.5 Gilson ThermoQuest 216

6.3 Analysis of Combinatorial Libraries 216

6.3.1 Purity of Combinatorial Libraries 217

6.3.2 Identity of Combinatorial Libraries 218

6.3.3 Quantification of Combinatorial Libraries 219

6.4 Automated Sample Processing 219

6.4.1 Sample Logistics 219

6.4.2 Evaporation 221 References 222

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