Cycloadditions in Combinatorial and Solidphase Synthesis 440

Markus Albers and Thorsten Meyer

16.1 Introduction 440

16.2 [4 + 2] Cycloadditions 441

16.2.1 Diels-Alder Reaction with Resin-bound Dienes 441

16.2.2 Diels-Alder Reaction with Resin-bound Dienophiles 445

16.2.3 Intramolecular Diels-Alder Reaction on Solid Support 448

16.2.4 Hetero-Diels-Alder Reaction on Solid Support 450

16.2.5 Diels-Alder Reaction in Solution Phase 451

16.3 [3 + 2] Cycloadditions 453

16.3.1 Formation of Isoxazoles, Isoxazolines, and Isoxazolidines 453

16.3.2 Formation of Pyrrolidines 458

16.3.3 Formation of Furans 460

16.3.4 Formation of Imidazoles, Pyrroles, Pyrazoles, and Other Nitrogen-containing Heterocycles 461

16.4 [2 + 2] Cycloadditions 463

16.5 [6 + 3] Cycloadditions on Solid Support 464

16.6 Rearrangements 465 References 467

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