Solid-phase chemistry has made tremendous progress during recent years, and today highly complex natural products can be prepared on solid supports (see Chapter 3). Nevertheless, method development is slow and often fails to produce the compounds needed, e.g. in medicinal chemistry optimization programs. Thus, careful validation of the possible outcome of solid-phase chemistry has to be given the highest priority before the development of methodology is started. However, for the preparation of large libraries with only minor time constraints, solid-phase chemistry remains the method of choice. On the other hand, solution-phase chemistry is much more flexible and quicker. However, the production of large libraries is very tedious owing to the difficult purification of the products.
Polymer-supported reagents and scavengers represent a versatile addition to solid-phase organic synthesis and parallel solution-phase chemistry. The combination of these reagents offers exciting possibilities. The methods described in this chapter are interesting and fascinating but, so far, they do not enable the chemist to exploit all the synthetic routes that he or she might think of. Thus, there is a need for more solid-supported reagents, linkers, scavengers, and, especially, solidphase methodology.
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