Similarly to the ''tea-bag'' approach, pieces of any solid-phase support suitable for solid-phase synthesis can be used for parallel peptide preparation. One of the first materials used in this manner was paper. Frank used paper disks [31, 32] (Whatman 3MM, 1.5 cm diameter) packed into columns of a multicolumn continuous flow synthesizer. Prior to the synthesis, the paper was derivatized with p-alkoxybenzyl linkage to allow for the cleavage with trifluoroacetic acid. The disks can easily be labeled with a pencil, sorted, and combined depending on the common amino acid to be coupled at the next step.
Cotton has mechanical properties superior to those of paper, and was used in a similar way by Lebl and colleagues [33, 34]. Researchers from the Rockefeller University used polystyrene-grafted polyethylene film [35, 36], whereas scientists from Pfizer used material prepared from two sheets of polypropylene mesh with resin sandwiched in between . The ''sandwich'' was fused together with a polymer with a low melting point.
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