Catalysts for Enantioselective Synthesis 991

Amir H. Hoveyda

33.1 Introduction 991

33.2 Factors Critical to the Success of Diversity-based Reaction Development 992

33.3 Peptidic Schiff Bases as Chiral Ligands 994

33.3.1 Ti-Catalyzed Enantioselective Addition of Cyanide to Meso Epoxides 995

33.3.2 Ti-Catalyzed Enantioselective Addition of Cyanide to Imines 1000

33.3.3 Zr-Catalyzed Enantioselective Addition of Dialkyl Zincs to Imines 1004

33.3.4 Cu-Catalyzed Enantioselective Addition of Dialkyl Zincs to Allylic Phosphates: Pyridyl Dipeptides as Chiral Ligands 1006

33.3.5 Cu-Catalyzed Enantioselective Conjugate Addition of Dialkyl Zincs to Unsaturated Ketones: Peptidic Phosphines as Chiral Ligands 1009

33.4 Conclusions and Outlook 1012 Acknowledgments 1013 Endnotes and References 1013

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