This drug is used cautiously in patients with bone marrow depression or severe hepatic or renal impairment. Zidovudine is a Pregnancy Category C drug and is used cautiously during pregnancy and lactation. There is an increased risk of bone marrow depression when zidovudine is administered with antineoplastic drugs, other drugs causing bone marrow depression, and in patients having or recently taking radiation therapy. An additive neurotoxicity may occur when zidovu-dine is administered with acyclovir. Clarithromycin decreases blood levels of zidovudine. The blood levels of zidovudine are increased when it is given with lamivudine.


• The Patient Receiving an Antiviral Drug

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