Nonsteroidal Antiinflammatory Drugs

These drugs are contraindicated in individuals with known hypersensitivity to an individual drug or any components of the drug. The NSAID flurbiprofen is con-traindicated in patients with herpes simplex keratitis. Diclofenac and ketorolac are contraindicated in patients who wear soft contact lenses (may cause ocular irritation).

The NSAIDs are used cautiously during pregnancy (Pregnancy Category C, flurbiprofen, ketorolac; Pregnancy Category B, diclofenac) and lactation. The NSAIDs are used cautiously in patients with bleeding tendencies. When used topically there is less risk of interactions with drugs or other substances. There is a possibility of a cross-sensitivity reaction when the NSAIDs are administered to patients allergic to the salicylates. The cortico-steroids and the antibiotics are used cautiously in patients with sulfite sensitivity because an allergic-type reaction may result. Co-administration of idoxuridine with solutions containing boric acid may cause irritation. The sulfonamides are incompatible with silver nitrate.

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