The peripheral vasodilating drugs are contraindicated in patients with known hypersensitivity to the drugs, women in the immediate postpartum period (isoxsuprine causes uterine relaxation), and in patients with arterial bleeding. Safe use during pregnancy has not been established (Pregnancy Category C). Cilostazol is contraindicated in patients with CHF and during pregnancy (Pregnancy Category C). These drugs are used cautiously in patients with bleeding tendencies, severe cerebrovascu-lar or cardiovascular disease, and after a myocardial infarction. There are no significant drug-drug interactions.
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