Cannabis in India ancient lore and modern medicine

GW Pharmaceuticals, 2235 Wylie Avenue, Missoula, MT 59809, USA Introduction Ayurvedic medicine India is a land steeped in faith and mysticism. Ayurveda, combining the Sanskrit words for life and knowledge, is a system of medicine intertwined inextricably with these traits. That a core of belief combined with empirical experimentation could produce a viable medical regimen still widely practiced after well over 3000 years is astounding to Western physicians. Cannabis was similarly bound to faith...

Cannabinoids and anxiety

Department of Psychology, University of Vermont, Burlington, VT 05405, USA As stated in Ethan Russo's chapter the first known reference to the use of Cannabis for the relief of anxiety was about 1500 bce in India. In modern times the 1860 Report of the Ohio State Medical Committee on Cannabis indica 1 stated As a calmative and hypnotic, in all forms of nervous inquietude and cerebral excitement, it will be found an invaluable agent, as it produces none of those functional derangement or...

The skeleton stone bones and stoned heads

Bone Laboratory, The Hebrew University of Jerusalem, Jerusalem 91120, Israel In vertebrates, bone mass is maintained constant between the end of linear skeletal growth, when the peak bone mass is established, and gonadal failure, when accelerated bone loss begins. The bone mass is preserved by a continuous destruction formation process termed bone remodeling 1 . This destruction formation cycle occurs at the same time in multiple foci that in humans encompass approximately 5 of trabecular,...

Preface

Twenty years ago the endocannabinoid system was unknown. We knew much about the use over millennia of Cannabis plant preparations both as a medicine and as a drug that takes away the mind (as so-well stated in ancient Assyrian clay tablets). During the early part of the last century considerable progress was made on the chemistry and pharmacology of Cannabis, but it was only after the identification in 1964 of A9-tetrahydrocannabinol (A9-THC) as the active constituent of the plant that this...

Info

Parahippocampal activity 145 anxiety, CBrknockout mouse 143 anxiety, clinical trials, Marinol 146 anxiety, clinical trials, Nabilone 146 anxiety, clinical trials, Sativex 146 apomorphine 187 apoptosis 28, 75, 88, 170 appetite and cannabidiol 58, 219 appetite stimulation 13 application site reaction 255 2-arachidonoyl glycerol (2-AG) 26, 156, 184, 189, 190, 202, 259 arachidonoyl serotonin 156 arachidonoyl-serine (ARA-S) 234 asthma 10, 13 ataxia 98 Atharvaveda 2, 12 autoimmune disease 97 aversive...

The development of Sativex a natural cannabisbased medicine

Capitate Stalked Trichomes

GW Pharmaceuticals plc, Porton Down Science Park, Salisbury, Wiltshire SP4 OJQ, UK Cannabis has been used medicinally for 4000 years 1-4 in a variety of cultures and was re-introduced into British medicine in 1842 by W. O'Shaughnessy 5 . It remained in the British pharmacopaeia until 1932, when cannabis, extract of cannabis and tincture of cannabis were among 400 medicines removed, though all three remained in the British Pharmaceutical Codex of 1949 5 . However, following the 1961 UN Single...

Cannabinoids in appetite and obesity

Francis Barth and Murielle Rinaldi-Carmona Sanofi-aventis, 371, rue du Professeur Joseph Blayac, 34184 Montpellier Cedex 04, France In contrast to most drugs, many of the pharmacological activities of cannabinoids were described in humans before being investigated by pharmacologists in laboratory animals. This peculiarity is of course due to the use of Cannabis sativa preparations for recreational purposes from ancient civilizations up to modern times. The effects of cannabinoids on appetite...

Endocannabinoids and regulation of fertility

Department of Biomedical Sciences, University of Teramo, Piazza A. Moro 45, 64100 Teramo, Italy The adverse effects of cannabinoids, and in particular of A9-tetrahydro-cannabinol (A9-THC), on reproductive functions have been known for a long time 1,2 , and include retarded embryo development, fetal loss and pregnancy failure (recently reviewed in 3, 4 ). A9-THC has been reported to account for the majority of the reproductive hazards of marijuana use, in particular in males it leads to...

Cannabinoid chemistry an overview

Cannabinoid Chemistry

Hanus and Raphael Mechoulam Department of Medicinal Chemistry and Natural Products, Medical Faculty, The Hebrew University of Jerusalem, Ein Kerem Campus, 91120 Jerusalem, Israel Cannabis sativa probably originates from neolithic China 1 . However the exact period of its domestication is unknown. The first known record of the use of cannabis as a medicine was published in China 5000 years ago in the reign of the Emperor Chen Nung. It was recommended for malaria, constipation, rheumatic...

Hd

HD is an inherited neurodegenerative disorder characterized by motor abnormalities, cognitive dysfunction and psychiatric symptoms, which presents in mid life and is ultimately fatal (for review, see 115, 116 ). The most striking neuropathological change in HD patients is the preferential and progressive degeneration of the striatum due to the selective death of striatal projection neurons (these neurons contain CBj receptors 134 ), which is accompanied by a biphasic pattern of motor...