Drug Discrimination

1. Rodents are trained to discriminate cannabinoids from drugs of other classes, and they will generalize responses to other cannabinoids.

2. In the drug-discrimination paradigm (see ref. 19 and Note 3), laboratory animals learn to recognize the presence of a certain drug (such as nicotine, morphine, LSD, A9-THC) and express the discrimination between the drug under investigation and a control substance (placebo) in a two-choice situation, where the correct choice is rewarded.

A AMBULATION

A AMBULATION

Dose (mg/kg)

A THC

C HYPOTHERMIA

C HYPOTHERMIA

Dose (mg/kg)

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