Introduction

Liver Cancer Planting Transfer

Cannabinoid was originally the collective name given to a set of oxygen-containing C21 aromatic hydrocarbon compounds that occur naturally in the plant Cannabis sativa (ElSohly 2002 Mechoulam and Gaoni 1967). However, this term is now generally also used for all naturally occurring or synthetic compounds that can mimicthe actions of plant-derived cannabinoids or thathave structures that closely resemble those of plant cannabinoids. Consequently, a separate term, phyto-cannabinoid, has been...

Receptors for Abnormal Cannabidiol

There is evidence, mainly from in vitro experiments with rat or mouse phenylephrine- or methoxamine-precontracted buffer-perfused isolated mesenteric arterial beds or isolated mesenteric arterial segments, for the presence in these tissues of non-CB1, non-CB2 receptors with which anandamide and methanandamide can interact to induce a relaxant effect (reviewed in Howlett et al. 2002 Pertwee 2004a Wiley and Martin 2002). There are several reasons for believing that these are not CB1 or CB2...

Cannabinoid Receptor Agonists

Cannabinoid Examples

In terms of chemical structure, established cannabinoid receptor agonists fall essentially into four main groups classical, nonclassical, aminoalkylindole and eicosanoid (reviewed in Howlett et al. 2002 Pertwee 1999a). - The classical group consists of dibenzopyran derivatives that are either cannabis-derived compounds (phytocannabinoids) or their synthetic analogues. Notable examples are the phytocannabinoids49-THC,48-THC and cannabinol (Fig. 1), and the synthetic cannabinoids, JWH-133,...