Neurochemistry Of Gaba

Brain Neurochemistry

The synthesis and metabolism of GABA is closely linked with that of glutamate and the citric acid or tricarboxylic acid (TCA) cycle (Fig. 11.1). GABA is produced by the decarboxylation of glutamate, a reaction catalysed by the enzyme glutamic acid decarboxylase (GAD). GAD is found in several non-neuronal tissues (including ovary and pancreas) but within the CNS it is a specific marker of GABAergic neurons, where it is present in the cytoplasm as both soluble and membrane-bound forms,...