Laboratory Adulteration Reagents

To prevent specimen adulteration, laboratories have instituted adulterant testing. Reagents for such use are available through companies such as Sciteck Diagnostics, Inc., and Axiom Diagnostics, Inc. Tests for pH, specific gravity, creatinine, glutaraldehyde, and various oxidants are available. However, not all the laboratories test for all the parameters routinely. Moreover, additional

Department of Transportation (DOT) and Substance Abuse and Mental Health Services Administration (SAMHSA) Validation Criteria

DOT

SAMHSA

Criteria

Adulterated

Substituted

Diluted

Adulterated

Substituted Diluted

Invalid

Creatinine

<5 mg/dL

<20 mg/dL

<2 mg/dL >2 mg/dL and <20 mg/dL

Inconsistent result

Specific

<1.001 or

<1.003

<1.0010 or >1.0010 but

Inconsistent result

Gravity

>1.020

>1.0200 <1.0030

pH

<3 or >11

<3 or >11

>3 and <4.5; >9 and <11

Nitrite

>500 ng/mL

>500 ng/mL

>200 |lg/mL

Glutaraldehyde

Presence

Presence

Chromium (VI)

>50 |lg/mL

>50 |lg/mL

Pyridine

>200 |lg/mL Nitrite equivalent or >50 |lg/mL Chromium (VI)-equivalent

Halogen

Same as pyridine

Presence

Surfactant

dodecylbenzene sulfonate-equivalent

Same as adulterated

Others

Oxidant presence. Immunoassay interference, equipment damage, appearance

charges are sometimes added to the cost of the drug tests for specimen validity testing, which further hinder widespread use.

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