Tropane alkaloids have a tropane (C4N skeleton +) nucleus. Structurally, these alkaloids synthesize as postcursors of pyrrolines (Figure 57). a, 0, y and x in the tropane pathway are the same as in pyrrolines. Typical tropane alkaloids (e.g., atropine, hyoscyamine, cocaine, tropinone, tropine, littorine and cuscohy-grine) have a strong biological activity, especially as neurotransmitters.
Urea cycle (animals)
Hydrolysis of imine functionality in guanidine system
Hydrolysis of urea
CH3 (-)-hygrine CH3 (+)-hygrine
Figure 56. Structural development of pyrrolidine alkaloids.
Continue reading here: Imidazole alkaloids
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