In the case of protein amino acid-derived alkaloids, the second obligatory intermedia is synthesized from the obligatory intermedia by chemical reactions. In the pelletierine synthesis pathway started with L-lysine, the second obligatory intermedia is A1-piperidinium cation. It is formed by a Mannich reaction from A1-piperidine (obligatory intermedia) and COSCoA. The second obligatory intermedia, by hydrolysis decarboxylation, produces pelletierine.
In the case of non-protein amino acid-derived alkaloids, the second obligatory intermedia is derived from the obligatory intermedia enzymatically and by the Schiff base formation as, for example, in the hygrine pathway. The second obligatory intermedia is, in this case, the N-methyl-A1-pyrrolinium cation.
The general characteristic of the second obligatory intermedia is that this compound is not stable. It is poison and biologically active. Subsequently, the second intermedia alkaloid is synthesized.
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