Quinazoline alkaloids

Quinazoline alkaloids contain more than 100 compounds. They have been isolated from animal and plant sources. The plant family Rutaceae is especially rich in these alkaloids. Typical quinazoline alkaloids include, for example, arborine, glomerin, homoglomerin, glycorine, glycosminine, febrifugine and

L-histidine

Isopilocarpine

Pilocarpine

CH3 N

? = no experimental evidence

Dolichotheline

Figure 58. Structural development of imidazole alkaloids.

L-leusine

Histamine

Pilosine vasicine (Figure 59). The a of quinazoline alkaloids is anthranilic acid, though there are also in some cases alternative a, such as phenylalanine in the case of arborine or ornithine. The ft is anthranoylphenylalanine.

Quinazoline alkaloids are known as biologically active compounds. Arborine inhibits the peripheral action of acetylcholine and induces a fall in blood pressure. Febrifugine is an anti-malarial agent and vasicine acts as a uterine stimulant. Glomerin and homoglomerin are alkaloids of the defensive system in some organisms (e.g., in the glomerid millipede).

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