Estrogenic effects

Biological activity, although typical for alkaloids, can be very different and dependent on the chemical structure of alkaloid molecules. Quinoline alkaloids extracted from the plant belonging to the genus Haplophyllum A. Juss. (family Rutaceae) have strong biological activity with an estrogenic effect54. The receptor for estrogenic activity is located in the nucleus (Figure 84). Therefore, this activity can be considered initiated with these receptors.

Empirical results with 15 quinoline alkaloids have been received in the study with mature intact rats. It was found that all the alkaloids studied (y-fagarine, haplopine, skimmianine, glycoperine, evoxine, dubinidine, dubinine, perforine, haplophyllidine, perfamine, bucharidine, folifidine, acetylfolifidine, foliosidine and acutine) cause the uterus to hydrate. Some alkaloids changed the menstrual cycle of mature intact rats by lengthening the oestrus phase. If the average duration of a single menstruation was 1 day, the alkaloids extended it to 1.4 days54. However, there were differences between the alkaloids studied concerning the intensity of estrogenic activity. According to the results,

A

Figure 84. Diagram of estrogenic activity of the alkaloids. Abbreviations: R - receptor; HSP - heat shock proteins.

quinoline alkaloids have the highest estrogenic activity at doses from 50 to 100mgkg-1. This interesting study also observed that the estrogenic activity of perforine was many times greater than that of haplophyllidine. According to Nazrullaev et al.54, estrogenic activity depends on the heterocyclic skeleton, N and the nature of the substituent.

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