Acridone alkaloids

Fewer than 100 acridone alkaloids are known. Typical compounds include, for example, atalaphylline, acronycine and preacronycine. Acridone alkaloids occur in plants and animals. They are especially characteristic of the Rutaceae plant

L-ornithine

Anthranilic acid

CO2H

. COSCoA

Anthranilic acid

. COSCoA

Nucleophilic attack of Anthraniloyl-CoA amine to the iminium a

CO2H

CO2H

CO2H

L-asparagine

Vasicine (pegamine)

Vasicine (pegamine)

Figure 59. Structural development of quinazoline alkaloid vasicine.

family. The a is anthranilic acid, the ft is N-methyl anthraniloyl-CoA, and the ^ is 1,3-dihydroxy-N-methylacridone (Figure 60). Acridone alkaloids are biologically active. Acronycine is also known for its antitumour activity.

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