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Uses. Trenbolone is a familiar agricultural drug used for encouraging growth in meat animals. Human bodybuilders have used the substance in hopes of gaining competitive advantage.

Drawbacks. The drug can promote masculine characteristics in females. Research on the drug's effects in pigs noted that testes decreased in size; research on cows noted disruption of ovarian cycles. Reports exist of human users complaining about headache, high blood pressure, nosebleeds, acne, fever, loss of appetite, queasy stomach, darkened urine, and aggressive conduct while taking the substance.

Abuse factors. Muscle mass has increased in steers receiving a growth treatment that included the drug. Some bodybuilders and weight lifters use various forms of trenbolone, making little distinction among them. The drug, however, is banned from sports competitions (including horse racing).

Drug interactions. Not enough scientific information to report.

Cancer. Laboratory tests generally have not revealed trenbolone to have a cancer-causing potential, but the substance has nonetheless been associated with cancer in mice and rats. Some researchers believe tumors probably result from hormonal effects of trenbolone dosage rather than a direct chemical action (the practical consequence may be the same for an animal either way, but the difference is important for scientists seeking better understanding of the drug).

Pregnancy. Animal experiments do not indicate that the drug causes birth defects, but women are routinely advised to avoid drugs of this type during pregnancy.

Additional scientific information may be found in:

Johnson, B.J., et al. "Effect of a Combined Trenbolone Acetate and Estradiol Implant on Feedlot Performance, Carcass Characteristics, and Carcass Composition of Feedlot Steers." Journal of Animal Science 74 (1996): 363-71.

Peters, A.R. "Effect of Trenbolone Acetate on Ovarian Function in Culled Dairy Cows." Veterinary Record 120 (1987): 413-16.

Richold, M. "The Genotoxicity of Trenbolone, a Synthetic Steroid." Archives of Toxicology 61 (1988): 249-58.

Van Leeuwen, F.X. "The Approach Taken and Conclusions Reached by the Joint FAO-WHO Expert Committee on Food Additives." Annales de Recherches Veterinaires— Annals of Veterinary Research 22 (1991): 253-56.

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