Pregnancy Category None
Uses. This drug is somewhat like meperidine but has no officially sanctioned medical use in the United States. Elsewhere it is used as a pain reliever. Australian work has examined using trimeperidine, meperidine, and methadone together for pain control. In Russia trimeperidine is given to adults and children both and has been used to treat shock (low blood pressure and heartbeat abnormality) as well as pain. A report from a Moscow surgery facility indicated that trimeperidine is used routinely there and implied that patients are allowed to select whatever dosage is effective for them. Another report from Russia judged the substance to be an excellent choice for anesthesia in abdominal cancer operations, although an additional study described the drug as less effective than fentanyl in anesthesia. Trimeperidine has been used to ease childbirth, but a clinical report from Bulgaria says that other drugs work better. Russian military medicine used trimeperidine for treating combat casualties evacuated from the Afghanistan and Chechnya wars but found it less effective than other pharmaceuticals. In the 1980s Russian research studied possible uses for the drug in treating combined burn and radiation injuries, a direction of research suggesting preparation for nuclear war.
Drawbacks. The drug has been known to halt breathing.
Abuse factors. A rat study demonstrated that dependence can develop with trimeperidine.
Drug interactions. Not enough scientific information to report.
Cancer. Not enough scientific information to report.
Pregnancy. Not enough scientific information to report.
Additional information. Trimeperidine and the Schedule I substances al-phameprodine (CAS RN 468-51-9), betameprodine (468-50-8), and prohepta-
zine (77-14-5) all have the same molecular formula, but they are different drugs.
Additional scientific information may be found in:
Alderman, C. "Trimeprazine as a Component of Pain Cocktails." Australian Journal of Hospital Pharmacy 19 (1989): 205-6.
Bazarevich, G.I., et al. "Sravnitel'naia otsenka protivoshokovogo deistviia nekotorykh otechestvennykh farmakologicheskikh preparatov" (Comparative evaluation of antishock activity of various Soviet pharmacological agents) (In Russian). Vestnik Khirurgii Imeni I. I. Grekova 130, no. 6 (1983): 73-77.
Il'iuchenok, T.Iu., I.A. Matveeva, and R.O. Budagov. "Changes in the Pharmacodynamic Properties of Promedol, Droperidol and Dimedrol in Burn Shock and Combined Radiation-Thermal Injury" (in Russian). Farmakologiia i Toksikologiia 50 (1987): 71-74.
Kichin, V.V., and M.Iu. Buldakov. "Anesthesiological Accompaniment for the Wounded during Transport" (in Russian). Voenno-Meditsinskii Zhurnal 320 (1999): 23-26, 96.
Malinovskii, N.N., R.N. Lebedeva, and V.V. Nikoda. "The Problem of Acute Pain in Postoperative Period" (in Russian). Khirurgiia (Mosk), no. 5 (1996): 30-35.
Radev, R. "Postoperative Analgesia in Cesarean Section" (in Bulgarian). Khirurgiia (So-fiia) 49 (1996): 33-36.
Shcherbakov, I.V., et al. "The Choice of a Method of General Anesthesia for Patients with Cancer of the Abdominal Cavity" (in Russian). Anesteziologiia i Reanimato-logiia, nos. 5-6 (1992): 48-50.
Note: English summaries of all the above articles are available through the
PubMed Web site: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi
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