Methandrostenolone

Pronunciation: meth-an-droh-STEN-oh-lohn Chemical Abstracts Service Registry Number: 72-63-9 Formal Names: Anabolin, Dianabol, Methandienone, Nerobol Type: Anabolic steroid. See page 24 Federal Schedule Listing: Schedule III (DEA no. 4000) USA Availability: Prescription

Uses. Medical uses of methandrostenolone include promoting growth in small boys, although with the risk of accelerating increase in height for awhile and then stopping further increase permanently. The drug has also been used to bring on male puberty when that development is delayed. A research study found that the substance increases sexual desire in men while simultaneously reducing their fertility. The drug has been given to control hereditary angio-edema, a disease producing giant hives on the skin. A lung disease called silicosis has been treated with the drug, and so have burns, cancer, and a type of anemia. Using the substance against a brittle bone condition called osteoporosis has been tried, with mixed results. Protection against lead poisoning was noted in a rat experiment. Levels of triglycerides, which are associated with heart attack and stroke, declined in diabetic humans who received the drug.

The substance is forbidden in sports competitions, but some athletes continue to use it, either because they will not be tested for it or because they hope to evade tests. Experiments have compared athletes using methandro-stenolone to others not receiving the drug (either two different groups of athletes were compared, or the same volunteers were tested under both drug and nondrug conditions). In one study the drug group showed higher increase in weight and strength. In another experiment the drug group gained more weight than the drug-free group, but the scientists noted that water retention could have been the reason. Blood pressure also increased in the drug group. In still another comparison experiment the methandrostenolone users gained more weight and achieved more muscle development, but despite additional muscle mass their strength and performance did not differ from the drug-free group—scientists running those tests were unsure that anabolic steroid actions explained physical development in the drug group; as with an experiment mentioned above, a plausible alternative explanation was that methandrosten-

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